Investigation of azobenzene-functionalized (2-phenylpyridine)Pt(II) complexes as switchable luminescent probes for amyloid fibrils

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Polyhedron Pub Date : 2025-01-08 DOI:10.1016/j.poly.2025.117394

Zhuoheng Li, F. Christopher Pigge

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Abstract

Two new cyclometalated platinum(II) acetylacetone (acac) complexes have been prepared and characterized. Each complex features a 2-phenylpyridine (ppy) cyclometalating ligand substituted with a peripheral photoswitchable azobenzene group. Azobenzene trans to cis photoisomerization and thermally-induced cis to trans back-isomerization were examined using UV–visible and ¹H NMR spectroscopy. Solutions of both complexes were found to be non-luminescent when irradiated at 410 nm in various solvents of differing polarity. A turn-on emission response was observed, however, when the complex possessing a ppy ligand functionalized with an azobenzene unit via an amide linkage was treated with amyloid fibrils prepared from denaturation of hen egg-white lysozyme (HEWL). The emission response is ascribed to steric inhibition of azobenzene photoisomerization upon interaction of the complex with hydrophobic surfaces of HEWL fibrils. X-ray crystal structures of four new Pt(II) complexes are reported as well.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.