Antitumour potential of aminopolycarboxylate-oxidovanadium(IV) complexes against human osteosarcoma cells

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Polyhedron Pub Date : 2025-01-06 DOI:10.1016/j.poly.2025.117392

K. Chmur , A. Tesmar , K. Kazimierczuk , A. Sikorski , J. Budka , I. Inkielewicz-Stepniak , D. Wyrzykowski

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Abstract

Investigations on the complex salts that comprise the nitrilotriacetate oxidovanadium(IV) anions, [VO(nta)(H₂O)]⁻, and cations derived from the protonation of N-heterocyclic compounds have shown that their biological activities are highly dependent on the specific biological characteristics of cancer cells. These compounds have previously been reported as ineffective anticancer agents against prostate and breast cancer cells in vitro; however, they exhibited significant selectivity for malignant cells in one particular case. As a result, these compounds demonstrate potential as antitumor agents in osteosarcoma models that involve bone-related cells in vitro. In this paper, we validate the previous findings by investigating the biological action of three [VO(nta)(H₂O)]⁻ salts with 4,4′-dimethoxy-2,2′-bipyridinium [4,4′-dmo-2,2′-(bpy)H]⁺, quinolinium [QH]⁺, and acridinium [(acr)H]⁺ counterions, namely [4,4′-dmo-2,2′-(bpy)H][VO(nta)(H₂O)]H₂O (1), [QH][VO(nta)(H₂O)](H₂O)₂ (2), [(acr)H][VO(nta)(H₂O)](H₂O)₂ (3) towards the human osteosarcoma cell line (MG-63) and the normal osteoblast cell line hFOB 1.19. Additionally, the crystal structure of [4,4′-dmo-2,2′-(bpy)H][VO(nta)(H₂O)]H₂O (1) is presented. The compounds studied showed a selective cytotoxic effect on tumour cells, with the selectivity index increasing in the following order 1 < 2 < 3. The mechanism of action of these salts on cells is not yet fully understood. However, these types of oxidovanadium(IV) compounds show promise as potential anticancer agents for human osteosarcoma cells.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.