Antitumour potential of aminopolycarboxylate-oxidovanadium(IV) complexes against human osteosarcoma cells

IF 2.6 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR Polyhedron Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI:10.1016/j.poly.2025.117392

K. Chmur , A. Tesmar , K. Kazimierczuk , A. Sikorski , J. Budka , I. Inkielewicz-Stepniak , D. Wyrzykowski

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Abstract

Investigations on the complex salts that comprise the nitrilotriacetate oxidovanadium(IV) anions, [VO(nta)(H₂O)]⁻, and cations derived from the protonation of N-heterocyclic compounds have shown that their biological activities are highly dependent on the specific biological characteristics of cancer cells. These compounds have previously been reported as ineffective anticancer agents against prostate and breast cancer cells in vitro; however, they exhibited significant selectivity for malignant cells in one particular case. As a result, these compounds demonstrate potential as antitumor agents in osteosarcoma models that involve bone-related cells in vitro. In this paper, we validate the previous findings by investigating the biological action of three [VO(nta)(H₂O)]⁻ salts with 4,4′-dimethoxy-2,2′-bipyridinium [4,4′-dmo-2,2′-(bpy)H]⁺, quinolinium [QH]⁺, and acridinium [(acr)H]⁺ counterions, namely [4,4′-dmo-2,2′-(bpy)H][VO(nta)(H₂O)]H₂O (1), [QH][VO(nta)(H₂O)](H₂O)₂ (2), [(acr)H][VO(nta)(H₂O)](H₂O)₂ (3) towards the human osteosarcoma cell line (MG-63) and the normal osteoblast cell line hFOB 1.19. Additionally, the crystal structure of [4,4′-dmo-2,2′-(bpy)H][VO(nta)(H₂O)]H₂O (1) is presented. The compounds studied showed a selective cytotoxic effect on tumour cells, with the selectivity index increasing in the following order 1 < 2 < 3. The mechanism of action of these salts on cells is not yet fully understood. However, these types of oxidovanadium(IV) compounds show promise as potential anticancer agents for human osteosarcoma cells.

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氨基聚羧酸-氧化钒（IV）复合物对人骨肉瘤细胞的抗肿瘤潜力

对由硝基三乙酸氧化钒（IV）阴离子、[VO(nta)(H2O)]−和n -杂环化合物质子化产生的阳离子组成的络合盐的研究表明，它们的生物活性高度依赖于癌细胞的特定生物学特性。这些化合物先前已被报道为对前列腺和乳腺癌细胞无效的体外抗癌剂；然而，在一个特殊的病例中，它们对恶性细胞表现出显著的选择性。因此，这些化合物在体外涉及骨相关细胞的骨肉瘤模型中显示出作为抗肿瘤药物的潜力。本文通过研究具有4,4′-二甲氧基-2,2′-联吡啶[4,4′-dmo-2,2′-(bpy)H]+、喹啉[QH]+和吖啶[(acr)H]+的三种[VO(nta)(H2O)]−盐，即[4,4′-dmo-2,2′-(bpy)H][VO(nta)(H2O)]H2O(1)]、[QH][VO(nta)(H2O)]（H2O)2(2)）、[(acr)H][VO(nta)(H2O)]（H2O)2(3)）对人骨肉瘤细胞株MG-63和正常成骨细胞株hFOB 1.19的生物学作用，验证了之前的发现。此外，还得到了[4,4 ' -dmo-2,2 ' -(bpy)H][VO(nta)(H2O)]H2O(1)的晶体结构。所研究的化合物显示出对肿瘤细胞的选择性细胞毒作用，其选择性指数按以下顺序递增1 <；2 & lt;3. 这些盐对细胞的作用机制尚不完全清楚。然而，这些类型的氧化钒（IV）化合物显示出作为人类骨肉瘤细胞潜在的抗癌剂的前景。

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.