Optical dual gas sensor for biomedical monitoring of NO and O2 based on electrospun fibers containing CsPbBr3 QDs and PtTFPP

Abstract

This study presents the design and development of an innovative optical dual gas sensor tailored for biomedical applications, enabling the simultaneous detection of nitric oxide (NO) and oxygen (O₂), critical biomarkers in physiological monitoring. The sensor leverages electrospun fibers embedded with CsPbBr₃ quantum dots (QDs) and platinum(II) meso-tetrakis(pentafluorophenyl) porphyrin (PtTFPP), offering a novel approach to enhancing gas-sensing capabilities. Electrospinning produces highly porous, uniform cellulose acetate fibers under optimized conditions (5 mL/hour flow rate, 17 kV supply voltage, 15 cm working distance), creating a biocompatible matrix that enhances sensor stability and responsiveness. The sensor is excited by a UV LED light source at 380 nm, with fluorescence intensities measured via spectrometry. It demonstrates excellent sensitivity, with maximum sensitivities of 4.2 for nitric oxide and 7.6 for oxygen, and rapid response/recovery times of 90 s/119 s for nitric oxide and 61 s/66 s for oxygen, respectively. These findings highlight the sensor’s potential for high-sensitivity, selective, and fast-response gas detection, making it a promising tool for real-time monitoring of respiratory gases and other biomedical applications.