Accurate determination of purity for organic compounds using adiabatic calorimetry

Abstract

Adiabatic calorimetry is a reliable method for determining the purity of organic compounds, offering significant advantages over chromatography by eliminating the need for impurity separation. Despite its longstanding application, research in this area has been limited. This study comprehensively assessed the purity of tetradecanoic acid, n-heptadecane, and phenol using adiabatic calorimetry, comparing the results with those obtained through chromatography. The results demonstrated that tetradecanoic acid purity can be accurately measured, while n-heptadecane exhibited satisfactory repeatability in purity determination without sample separation in polycrystalline forms. Furthermore, the purity of phenol was effectively assessed using adiabatic calorimetry, where chromatography faced challenges. Overall, this study validates adiabatic calorimetry as a robust technique for organic compound purity determination and suggests avenues for further research in this domain.