Etiopathogenesis and management updates on the comorbidity depression – Diabetes: A review of literature

Abstract

Comorbidity depression – diabetes is a common condition and is often associated with complications and high mortality. Both of these conditions are due to genetic predispositions associated with environmental factors. Many mechanisms explain the occurrence of this comorbidity. Two are the most studied: the involvement of oxidative stress and chronic inflammation. For the management, the management of depression in diabetics does not consist of a simple combination of antidepressants with antidiabetics but global management including medicinal and non-drug means. New drugs targeting NRH2 are in development. They would act on comorbidity depression – diabetes at the same time.