Investigating the synergistic effects of gamma-glutamyl transferase with homocysteine, ferritin, and uric acid in patients with type II diabetes mellitus

Q3 Medicine Endocrine and Metabolic Science Pub Date : 2024-12-12 DOI:10.1016/j.endmts.2024.100211

Simin Shirvani , Masomeh Halvaeezade , Maryam Avazzade , Morteza Golbashirzadeh , Atousa Moradzadegan

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Abstract

Background and aim

Type 2 diabetes mellitus (T2DM) is a growing public health concern, with oxidative stress implicated in its onset and progression. This study evaluates the synergistic effects of gamma-glutamyl transferase (γ-GT) as a marker of oxidative stress with homocysteine (Hcy), uric acid (UA), and ferritin in T2DM patients compared to healthy individuals.

Material and methods

This case-control study included 200 participants, with 100 T2DM patients and 100 age- and sex-matched healthy individuals from the Ahvaz Pasteur pathology laboratory. Serum glucose and ferritin levels were measured using the Cobas E411 autoanalyzer (ECL method), and γ-GT, Hcy, and UA levels were measured using the Pentra C400 analyzer (photometric method). Data were analyzed using XLSTAT and SPSS software.

Results

A significant correlation was found between fasting blood sugar (FBS) and 2-h postprandial (2hpp) glucose levels with ferritin serum levels (P < 0.001, r = 0.419 and P = 0.002, r = 0.290, respectively), indicating ferritin's role in T2DM development. Ferritin levels were significantly related to γ-GT levels (P < 0.001, r = 0.359) and correlated with Hcy (P = 0.001, r = 0.336) and UA (P = 0.02, r = 0.218) in T2DM patients.

Conclusion

This study highlights the role of oxidative stress and the synergistic effects of γ-GT and ferritin in T2DM development, underscoring their potential as cost-effective and widely available markers for predicting T2DM in clinical practice. Unlike previous studies, which focused individually on oxidative stress markers, this research uniquely combines γ-GT with Hcy, UA, and ferritin, providing a comprehensive assessment of oxidative stress in T2DM patients.

Main points

1.
Role of Oxidative Stress in T2DM: The study investigates the role of oxidative stress markers, particularly gamma-glutamyl transferase (γ-GT) and ferritin, in the development of Type 2 diabetes mellitus (T2DM).
2.
Correlation with Other Biomarkers: Significant correlations were found between ferritin levels and other biomarkers such as fasting blood sugar (FBS), 2-hour postprandial (2hpp) glucose, homocysteine (Hcy), and uric acid (UA) in T2DM patients.
3.
Predictive Value in Clinical Practice: The study highlights the potential of γ-GT and ferritin as cost-effective and widely available assays for predicting T2DM in clinical practice

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