Facile and diverse synthesis of indolyl substituted 4,5,6,7-tetrahydro-4H-indol-4-ones and 1,6-dihydropyrrolo[2,3-c]pyrazol via multi-component reactions

Abstract

An efficient and facile protocol for the synthesis of some novel 4,5,6,7-tetrahydro-4H-indol-4-ones, 1,6-dihydropyrrolo[2,3-c]pyrazol and 1,4-dihydrochromeno [4,3-b]pyrrol by one-pot three-component reaction of 3-cyanoacetyl indoles, arylglyoxal monohydrate and various enaminones, pyrazol-5-amines or 4-amino coumarin. The advantages of this method include the availability of starting materials, mild reaction conditions and good yields of products, operational simplicity.