Danyang Zhang PhD , Xuanhao Wang PhD , Lianlian Zhu MS , Yuxing Chen PhD , Chao Yang PhD , Zhiwei Zhong MS , Xiangming Kong MS , Jinliang Nan PhD , Chen Wang PhD , Hengxun Hu PhD , Jinghai Chen PhD , Peng Shi PhD , Xinyang Hu MD, PhD , Wei Zhu PhD , Jian’an Wang MD, PhD
{"title":"TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla","authors":"Danyang Zhang PhD , Xuanhao Wang PhD , Lianlian Zhu MS , Yuxing Chen PhD , Chao Yang PhD , Zhiwei Zhong MS , Xiangming Kong MS , Jinliang Nan PhD , Chen Wang PhD , Hengxun Hu PhD , Jinghai Chen PhD , Peng Shi PhD , Xinyang Hu MD, PhD , Wei Zhu PhD , Jian’an Wang MD, PhD","doi":"10.1016/j.jacbts.2024.08.009","DOIUrl":null,"url":null,"abstract":"<div><div>Genetic fate mapping confirmed the existence of the TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that <em>Retnla</em> could serve as the signature gene for TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophages. Administration of recombinant protein of the <em>Retnla</em> gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4<sup>hi</sup>MHCⅡ<sup>hi</sup> macrophages or macrophage-specific loss of <em>Retnla</em> facilitated heart failure progression.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 1","pages":"Pages 65-84"},"PeriodicalIF":8.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JACC: Basic to Translational Science","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452302X24003231","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Genetic fate mapping confirmed the existence of the TIMD4hiMHCⅡhi macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that Retnla could serve as the signature gene for TIMD4hiMHCⅡhi macrophages. Administration of recombinant protein of the Retnla gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4hiMHCⅡhi macrophages or macrophage-specific loss of Retnla facilitated heart failure progression.
期刊介绍：
JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.
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