{"title":"Effects of essential fatty acid deficiency on renal papillary lipid methylation.","authors":"R F O'Dea, T P Green, A R Sinaiko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The relationship between lipid methylation and prostaglandin release was examined in rat renal papillae. Essential fatty acid deficiency (EFAD) was produced to deplete tissues of arachidonate precursors. The in vitro release of prostaglandin E was determined after exposure of the papillae to hypertonic sodium chloride. The EFAD animals were observed to have significantly less renal papillary lipid methylation than rats fed control diets (50%; P less than 0.05). However, stimulation of prostaglandin production in vitro was not accompanied by any detectable changes in total lipid methylation in tissues from either normal or EFAD rats.</p>","PeriodicalId":20659,"journal":{"name":"Prostaglandins, leukotrienes, and essential fatty acids","volume":"33 3","pages":"199-202"},"PeriodicalIF":2.9000,"publicationDate":"1988-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Prostaglandins, leukotrienes, and essential fatty acids","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The relationship between lipid methylation and prostaglandin release was examined in rat renal papillae. Essential fatty acid deficiency (EFAD) was produced to deplete tissues of arachidonate precursors. The in vitro release of prostaglandin E was determined after exposure of the papillae to hypertonic sodium chloride. The EFAD animals were observed to have significantly less renal papillary lipid methylation than rats fed control diets (50%; P less than 0.05). However, stimulation of prostaglandin production in vitro was not accompanied by any detectable changes in total lipid methylation in tissues from either normal or EFAD rats.
期刊介绍：
The role of lipids, including essential fatty acids and their prostaglandin, leukotriene and other derivatives, is now evident in almost all areas of biomedical science. Cell membrane behaviour and cell signalling in all tissues are highly dependent on the lipid constituents of cells. Prostaglandins, Leukotrienes & Essential Fatty Acids aims to cover all aspects of the roles of lipids in cellular, organ and whole organism function, and places a particular emphasis on human studies. Papers concerning all medical specialties are published. Much of the material is particularly relevant to the development of novel treatments for disease.
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