Effect of specialized pro-resolving mediators on knee joint inflammation

IF 2 4区医学 Q3 ORTHOPEDICS Knee Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI:10.1016/j.knee.2025.01.005

Chilan Bou Ghosson Leite , Alexander Bumberger , Domenico Franco , Marco Tulio Di Stefano , Christian Lattermann

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Abstract

Background

Chronic inflammation following knee injuries often results in persistent knee pain and post-traumatic osteoarthritis (PTOA). Understanding the inflammatory processes that follow a joint injury is crucial to effectively mitigate PTOA progression. While inflammation is an integral part of any healing response, unresolved, long-lasting inflammation can be detrimental to the joint. The resolution of inflammation is an active process coordinated by pro-resolving molecules, including specialized pro-resolving mediators (SPMs). While SPMs have been primarily studied in chronic inflammatory diseases, their role in degenerative knee conditions such as PTOA remains underexplored.

Methods

This review examines the process of inflammation and its resolution following knee joint injuries and subsequent PTOA, with a focus on the impact of SPMs.

Conclusions

SPMs play a key role in the resolution of inflammation and may offer potential benefits in the management of knee injuries to improve pain and prevent PTOA.

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专门的促进缓解介质对膝关节炎症的影响

背景：膝关节损伤后的慢性炎症常常导致持续的膝关节疼痛和创伤后骨关节炎（pta）。了解关节损伤后的炎症过程对于有效减轻pta进展至关重要。虽然炎症是任何愈合反应的一个组成部分，但未解决的、持久的炎症可能对关节有害。炎症的消退是一个积极的过程，由促分解分子协调，包括专门的促分解介质（SPMs）。虽然SPMs主要在慢性炎症性疾病中进行了研究，但它们在退行性膝关节疾病（如pta）中的作用仍未得到充分探讨。方法本综述探讨了膝关节损伤和随后的pta后的炎症过程及其消退，重点讨论了SPMs的影响。结论spms在炎症的缓解中起关键作用，并可能在膝关节损伤的治疗中提供潜在的益处，以改善疼痛和预防上睑下垂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Knee 医学-外科

CiteScore

3.80

自引率

5.30%

发文量

171

审稿时长

6 months

期刊介绍： The Knee is an international journal publishing studies on the clinical treatment and fundamental biomechanical characteristics of this joint. The aim of the journal is to provide a vehicle relevant to surgeons, biomedical engineers, imaging specialists, materials scientists, rehabilitation personnel and all those with an interest in the knee. The topics covered include, but are not limited to: • Anatomy, physiology, morphology and biochemistry; • Biomechanical studies; • Advances in the development of prosthetic, orthotic and augmentation devices; • Imaging and diagnostic techniques; • Pathology; • Trauma; • Surgery; • Rehabilitation.