{"title":"Cyclohexane-1,3-dione derivatives: Versatile precursors for total synthesis of natural products","authors":"Dharminder Sharma , Manish Kumar , Sandeep Kumar , Megha Mehta , Pralay Das","doi":"10.1016/j.tet.2024.134395","DOIUrl":null,"url":null,"abstract":"<div><div>Natural product synthesis is highly demanding but challenging area considering the limitation in the availability of starting materials. The synthesis of such natural products form commercially available cyclohexane-1,3-dione derivatives as inexpensive and versatile building block has stirred undisputable advancements. This review highlights the importance of cyclohexane-1,3-dione derivatives for the construction of bicyclic to hexacyclic natural products having diverse range of biological activities. A pool of 57 representative studies published in the last two decades has been covered with the discussion of the key components of each strategy.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"171 ","pages":"Article 134395"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024005763","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Natural product synthesis is highly demanding but challenging area considering the limitation in the availability of starting materials. The synthesis of such natural products form commercially available cyclohexane-1,3-dione derivatives as inexpensive and versatile building block has stirred undisputable advancements. This review highlights the importance of cyclohexane-1,3-dione derivatives for the construction of bicyclic to hexacyclic natural products having diverse range of biological activities. A pool of 57 representative studies published in the last two decades has been covered with the discussion of the key components of each strategy.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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