Yin Yang 1: Function, Mechanisms, and Glia

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Neurochemical Research Pub Date : 2025-02-04 DOI:10.1007/s11064-025-04345-7

Ada G. Rodríguez-Campuzano, Francisco Castelán, Luisa C. Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Arturo Ortega

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Abstract

Yin Yang 1 is a ubiquitously expressed transcription factor that has been extensively studied given its particular dual transcriptional regulation. Yin Yang 1 is involved in various cellular processes like cell cycle progression, cell differentiation, DNA repair, cell survival and apoptosis among others. Its malfunction or alteration leads to disease and even to malignant transformation. This transcription factor is essential for the proper central nervous system development and function. The activity of Yin Yang 1 depends on its interacting partners, promoter environment and chromatin structure, however, its mechanistic activity is not completely understood. In this review, we briefly discuss the Yin Yang 1 structure, post-translational modifications, interactions, mechanistic functions and its participation in neurodevelopment. We also discuss its expression and critical involvement in the physiology and physiopathology of glial cells, summarizing the contribution of Yin Yang 1 on different aspects of cellular function.

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阴阳1：功能、机制和神经胶质

阴阳1是一种普遍表达的转录因子，由于其特殊的双转录调控作用而被广泛研究。阴阳1参与多种细胞过程，如细胞周期进程、细胞分化、DNA修复、细胞存活和凋亡等。它的功能失调或改变会导致疾病甚至恶性转化。这种转录因子对中枢神经系统的正常发育和功能至关重要。阴阳1的活性取决于其相互作用的伙伴、启动子环境和染色质结构，但其机制活性尚不完全清楚。本文就阴阳1的结构、翻译后修饰、相互作用、机制功能及其在神经发育中的作用作一综述。我们还讨论了它的表达及其在神经胶质细胞生理和生理病理中的重要作用，总结了阴阳1在细胞功能的不同方面的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurochemical Research 医学-神经科学

CiteScore

7.70

自引率

2.30%

发文量

320

审稿时长

6 months

期刊介绍： Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.