The relationship between regional mechanical properties and hemodynamic indices of the aortic arch: a preliminary study.

IF 3 3区医学 Q2 BIOPHYSICS Biomechanics and Modeling in Mechanobiology Pub Date : 2025-02-05 DOI:10.1007/s10237-025-01927-w

Yawei Zhao, Yifan Cao, Fen Li, Chenjia Zhang, Yike Shi, Hui Song, Lingfeng Chen, Weiyi Chen

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Abstract

This study aimed to investigate the relationship between regional elastic modulus and corresponding hemodynamic indices of healthy aortic arch. Porcine aortic arches (n=18) were obtained from a local abattoir and divided into 24 regions along axial and circumferential directions. Regional elastic modulus was measured by indentation tests, and elastic fiber content was assessed using Elastica van Gieson (EVG) staining. Additionally, a porcine aortic model was reconstructed based on computed tomography angiography (CTA) images, and local hemodynamic indices were calculated by the two-way fluid-structure interaction (FSI) method. The elastic modulus and elastic fiber content were inclined to be lower on the outer curvature of the aortic arch, particularly showing significant differences at the distal end. A negative correlation was found between elastic modulus and time-averaged wall shear stress (TAWSS) $(r_{s} = - 0.762, p = 0.028$ ) at the proximal end of the porcine aortic arch. There was a significant positive correlation between elastic modulus and oscillatory shear index (OSI) $(r_{s} = 0.714, p = 0.047)$ at the middle of the aortic arch. The regional elastic modulus of healthy porcine aortic arch is associated with local TAWSS and OSI. The hemodynamic environment could be a contributing factor influencing the distribution of the mechanical properties on the arch.

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本研究旨在探讨健康主动脉弓区域弹性模量与相应血流动力学指标之间的关系。猪主动脉弓（n=18）取自当地屠宰场，沿轴向和周向分为 24 个区域。通过压痕测试测量区域弹性模量，并使用 Elastica van Gieson（EVG）染色法评估弹性纤维含量。此外，还根据计算机断层扫描血管造影（CTA）图像重建了猪主动脉模型，并通过双向流体-结构相互作用（FSI）方法计算了局部血流动力学指数。结果表明，主动脉弓外侧弯曲处的弹性模量和弹性纤维含量较低，尤其是在远端表现出显著差异。在猪主动脉弓近端，弹性模量与时间平均壁剪切应力（TAWSS）呈负相关（r s = - 0.762 , p = 0.028）。主动脉弓中部的弹性模量和振荡剪切指数（OSI）之间存在明显的正相关（r s = 0.714，p = 0.047）。健康猪主动脉弓的区域弹性模量与局部 TAWSS 和 OSI 相关。血液动力学环境可能是影响主动脉弓机械特性分布的一个因素。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.