{"title":"The Role of Small Extracellular Vesicles in Retinoblastoma Development and Progression.","authors":"Jyothi Attem, Geeta K Vemuganti","doi":"10.1080/02713683.2025.2457102","DOIUrl":null,"url":null,"abstract":"<p><p>A growing body of research on extracellular vesicles (EVs) in cancer has revealed their novel and crucial activities in the progression of tumors while also paving the way for potential therapeutic interventions. It is now known that EVs are natural delivery vehicles for particular payloads of source cells, enabling them to influence diverse functions of cells both in healthy and malignant cells. In this review, we comprehensively summarize mechanistic insights into sEV roles in RB, the most frequent intraocular malignancy that affects the retina of young children. We also explore the therapeutic potential of sEVs as an emerging area as biomarkers and vehicles for targeted therapy. Additionally, we address the potential challenges and limitations of translating sEVs-based technologies into clinical practice.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02713683.2025.2457102","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A growing body of research on extracellular vesicles (EVs) in cancer has revealed their novel and crucial activities in the progression of tumors while also paving the way for potential therapeutic interventions. It is now known that EVs are natural delivery vehicles for particular payloads of source cells, enabling them to influence diverse functions of cells both in healthy and malignant cells. In this review, we comprehensively summarize mechanistic insights into sEV roles in RB, the most frequent intraocular malignancy that affects the retina of young children. We also explore the therapeutic potential of sEVs as an emerging area as biomarkers and vehicles for targeted therapy. Additionally, we address the potential challenges and limitations of translating sEVs-based technologies into clinical practice.
IF 2.7 4区 医学Human ImmunologyPub Date : 2017-10-01DOI: 10.1016/j.humimm.2017.07.013
Caroline Xavier-Carvalho , Renata Duarte da Silva Cezar , Naishe Matos Freire , Carla Maria Mola de Vasconcelos , Victor Edgar Fiestas Solorzano , Thiago Gomes de Toledo-Pinto , Luciana Gomes Fialho , Rodrigo Feliciano do Carmo , Luydson Richardson Silva Vasconcelos , Marli Tenório Cordeiro , Paulo Baptista , Elzinandes leal de Azeredo , Rivaldo Venâncio da Cunha , Luiz José de Souza , Antonio Guilherme Pacheco , Claire Fernandes Kubelka , Patrícia Muniz Mendes Freire de Moura , Milton Ozorio Moraes
期刊介绍：
The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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