Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients.

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S503902

Zihan Wang, Tianyi Lan, Yuqiao Zhang, Zijia Guo, Hongwei Yu, Guiyao Sun, Zhitian Wang, Zeran Yan, Qingwen Tao, Yuan Xu

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Abstract

Objective: To observe how osteoarthritis (OA) and degree of fatigue affect are associated with pain levels in patients with fibromyalgia syndrome (FMS).

Methods: A cross-sectional study was conducted involving FMS patients. Data regarding the clinical features of the patients, including scores for pain-Visual Analogue Scale (VAS), Fatigue Scale-14 (FS-14) and other patient information, was collected. A multivariable logistic regression model was constructed to determine whether there is a true association between OA, degree of fatigue, and pain level in FMS patients. Restricted cubic spline (RCS) analysis was used to explore a potential non-linear relationship between degree of fatigue scores and pain levels in FMS patients. An interaction analysis based on the main regression model was performed to examine the interaction between OA and degree of fatigue.

Results: Among the FMS patients, the presence of OA was identified as a risk factor associated with higher pain-VAS scores (OR=2.777, 95% CI=1.377-5.601, P=0.004); furthermore, higher degree of fatigue scores on the FS-14 were found to be significantly associated with high pain level (OR=1.145, 95% CI=1.054-1.243, P=0.001). The RCS analysis demonstrated a linear relationship between increasing FS-14 scores and an elevated risk of high pain levels among FMS patients (P-non-linear=0.119, P-overall=0.008). The interaction analyses revealed a significant association between OA and degree of fatigue, which were related to the pain level of patients with FMS synergistically.

Conclusion: Patients with FMS experience coexisting OA and a high degree of fatigue, which interact synergistically, being correlated with increased pain levels.

Trial registration: The study was approved by the Clinical Research Ethics Committee of the China-Japan Friendship Hospital (2022-KY-079) and registered on ClinicalTrials.gov (NCT05508516) on August 17th, 2022.

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骨关节炎和疲劳程度与纤维肌痛综合征患者的疼痛程度有关：一项针对 394 名患者的横断面研究。

目的：观察纤维肌痛综合征（FMS）患者骨关节炎（OA）和疲劳程度与疼痛水平的关系。方法：对FMS患者进行横断面研究。收集患者的临床特征数据，包括疼痛-视觉模拟量表（VAS）评分、疲劳量表-14 （FS-14）评分及其他患者信息。构建多变量logistic回归模型以确定FMS患者的OA、疲劳程度和疼痛程度之间是否存在真正的关联。使用限制性三次样条（RCS）分析探讨疲劳程度评分与FMS患者疼痛水平之间潜在的非线性关系。基于主回归模型进行交互分析，考察OA与疲劳程度之间的交互作用。结果：在FMS患者中，OA的存在被确定为与较高的疼痛- vas评分相关的危险因素（OR=2.777, 95% CI=1.377-5.601， P=0.004）；此外，FS-14评分中较高的疲劳程度与高疼痛程度显著相关（OR=1.145, 95% CI=1.054-1.243， P=0.001）。RCS分析显示，FMS患者的FS-14评分增加与高疼痛程度风险增加之间存在线性关系（p -非线性=0.119,P-overall=0.008）。相互作用分析显示OA和疲劳程度之间存在显著的相关性，疲劳程度与FMS患者的疼痛程度协同相关。结论：FMS患者同时经历OA和高度疲劳，两者协同作用，与疼痛水平增加相关。试验注册：该研究已获得中日友好医院临床研究伦理委员会（2022- key -079）批准，并于2022年8月17日在ClinicalTrials.gov （NCT05508516）上注册。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.