Multifocal Necrotizing Sialometaplasia in the Tongue Surgical Specimen: An Immunohistochemical Study.

IF 4.1 Q2 PATHOLOGY Head & Neck Pathology Pub Date : 2025-02-05 DOI:10.1007/s12105-025-01756-4

Marcelo Borges Marques, Gabriela Esperanza Maradiaga Posantes, Luana Stefanie Silvino Gonçalves, Anderson Tangerino Ferreira da Silva, Heitor Albergoni Silveira, Fernando Chahud, Jorge Esquiche León

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Abstract

Background: Necrotizing sialometaplasia (NSM) is a rare self-limiting inflammatory lesion, with most cases affecting the minor salivary glands, especially those located in the palate (70%). To date, about 261 cases of NSM have been reported. Of them, 7 cases affected the tongue; 37 cases occurred after surgery; and 17 cases showed association with neoplasms.

Methods: A 50-year-old male patient was diagnosed with squamous cell carcinoma (SCC) of the tongue. After surgical excision, the tumor diagnosis was well-differentiated SCC with a close surgical margin. Re-excision of the margin was indicated.

Results: Microscopically, the surgical margin showed neither residual SCC nor epithelial dysplasia. However, it was possible to observe 7 foci containing typical areas of NSM distributed throughout the surgical specimen, which, by immunohistochemistry, revealed a glandular nature with presence of myoepithelial cells.

Conclusion: We present here an unusual multifocal NSM affecting the tongue at the site of a prior resection for SCC with close margins, which, to the best of our knowledge, has not been reported to date.

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舌头手术标本中的多灶性坏死性鞘膜积液：免疫组化研究。

背景：坏死性唾液化生（NSM）是一种罕见的自限性炎症性病变，大多数病例影响小涎腺，尤其是位于腭部的涎腺（70%）。迄今为止，已报告约261例NSM病例。其中舌部病变7例；术后37例；伴有肿瘤17例。方法：一位50岁男性患者被诊断为舌鳞癌（SCC）。手术切除后，肿瘤诊断为高分化鳞状细胞癌，手术切缘紧密。建议再次切除切缘。结果：镜下，手术边缘未见鳞状细胞癌残留，也未见上皮异常增生。然而，在整个手术标本中可以观察到7个包含典型NSM区域的病灶，通过免疫组化，显示了肌上皮细胞存在的腺体性质。结论：我们在这里提出了一种不寻常的多灶性NSM，影响舌头在先前切除的鳞状细胞癌与近缘，这是据我们所知，迄今为止尚未报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.