Evaluation of ultrasound derived fat fraction for metabolic associated fatty liver disease in obese patients with polycystic ovary syndrome.

Abstract

Objective: To explore the application of ultrasound derived fat fraction (UDFF) in evaluating metabolic associated fatty liver disease in obese polycystic ovary syndrome.

Method: This study included 124 obese PCOS patients and 106 age and body mass index (BMI) matched non PCOS control group women. The two groups of data were compared to determine the prevalence of metabolic associated fatty liver disease (MAFLD) in PCOS obese patients. The 124 obese PCOS patients were divided into MAFLD group (n = 64) and non MAFLD group (n = 60). Using ROC curve analysis to evaluate the diagnostic performance of UDFF and SWV values for MAFLD. The MAFLD group was divided into mild group (n = 16), moderate group (n = 24), and severe group (n = 24). Use Spearman correlation method to analyze the relationship between UDFF value, SWV value and the severity of MAFLD.

Result: MAFLD was more common in the obese PCOS group than in the control group (51.61 vs 27.36%) (χ² = 13.9583, P = 0.00019). The UDFF of obese PCOS patients was higher than those of the control group, while SWV was lower than those of the control group. ROC analysis showed that the AUC of UDFF for diagnosing MAFLD was 0.935, with sensitivity, specificity, and cut-off values of 92.2, 85.0, and 4.5%, respectively. UDFF was positively correlated with the severity of MAFLD (r = 0.603, P < 0.01). The AUC of SWE for diagnosing MAFLD was 0.728, with sensitivity, specificity, and cut-off values of 51.6, 93.3%, and 1.015 m/s, respectively. SWV was negatively correlated with the severity of MAFLD (r = - 0.551, P < 0.01).

Conclusion: The prevalence of MAFLD is significantly higher in obese PCOS patients, and UDFF technology can detect and quantitatively analyze liver fat infiltration in obese PCOS patients early. At the same time, auto-pSWE also has diagnostic significance for the progression of liver disease.