Yolk Sac Tumor of the Liver: An Important Differential for Liver Mass with Elevated Serum Alpha-Fetoprotein in the Pediatric Population.

IF 0.6 4区医学 Q4 PATHOLOGY Fetal and Pediatric Pathology Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI:10.1080/15513815.2025.2457616

Mai He, Kayla Hoerschgen, Amy E Armstrong, Lili Zhang, Patrick Dillon, Frances White, Louis P Dehner

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Abstract

Introduction: Yolk sac tumor (YST) is a malignant germ cell tumor with 10-15% arising in extragonadal sites. Methods: A search through our institution's database from January 01, 1990, to December 31, 2020, for "yolk sac tumor" or "endodermal sinus tumor" and "liver". Results: Our search yielded three cases. A 20-month-old girl with a liver mass and serum alpha-fetoprotein (AFP) level of 46558.0 ng/mL. The neoplasm was papillary with Schiller-Duval bodies. A 2-year-old boy with hepatic masses and adrenal mass with a serum AFP of 106,604.5 ng/mL. Numerous Schiller-Duval bodies were present. A 7-month-old girl with a liver mass, lung nodules, and retroperitoneal masses. Serum AFP was in the 800s ng/mL. Hepatoid and microcystic YST were mixed with hepatoblastoma (HBL). All three cases were positive for CAM5.2, SALL4, Glypican-3, beta-catenin, and AFP. Conclusion: Hepatic yolk sac tumor should be considered in the differential of a liver mass in pediatric patients with elevated AFP.

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肝卵黄囊肿瘤：小儿肝脏肿块与血清甲胎蛋白升高的重要鉴别依据

卵黄囊肿瘤（YST）是一种恶性生殖细胞肿瘤，发生率为10-15%，发生于卵黄囊外。方法：检索我院数据库1990年1月1日至2020年12月31日的“卵黄囊肿瘤”或“内胚层窦肿瘤”和“肝脏”。结果：我们的搜索产生了三个病例。20个月大的女婴，肝脏肿块，血清甲胎蛋白（AFP）水平46558.0 ng/mL。肿瘤呈乳头状，呈席勒-杜瓦尔小体。2岁男童，肝及肾上腺肿物，血清AFP 106,604.5 ng/mL。有许多席勒-杜瓦尔尸体。7个月大的女婴，肝脏肿块，肺结节，腹膜后肿块。血清AFP在800s ng/mL。肝样囊肿和微囊性囊肿与肝母细胞瘤（HBL）混合。3例均为CAM5.2、SALL4、Glypican-3、β -连环蛋白和AFP阳性。结论：小儿AFP升高时应考虑肝卵黄囊肿瘤。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.