{"title":"NAVT-net neuron attention visual taylor network for lung cancer detection using CT images","authors":"Lokanathan Jimson , John Patrick Ananth","doi":"10.1016/j.compbiolchem.2025.108363","DOIUrl":null,"url":null,"abstract":"<div><div>Lung Cancer is regarded as a common fatal disease affecting humans throughout the entire world. Early diagnosis is vital to save the patient’s life and Computed Tomography (CT) scans are referred to as the major imaging modes but, the manual examination of a CT scan is time-consuming and results in errors. Hence, a novel system of Neuron Attention Visual Taylor Network (NAVT-Net) is developed to detect lung cancer. At first, the CT image is acquired, and then, the input image is filtered based on homomorphic filtering. Then, the lung nodule is segmented using the Dual-Branch-UNet (DB-UNet). Later, the image augmentation is achieved by resizing, flipping, as well as rotation. Next, the shape-based features are extracted and subjected to the last stage of lung cancer detection, which is done by the NAVT-Net system that is established on the basis of Neuron Attention Stage-by-Stage Network (NASNet), Visual Geometry Group-16 (VGG16), and Taylor series. Hence, the experimental results of the developed NAVT-Net system achieved high values of 92.176 % accuracy, 93.997 % of True Positive Rate (TPR), 92.189 % of True Negative Rate (TNR), F1-score of 90.999 %, and precision of 91.998 %, computational time, and memory usage of 37.879 s, and 41.100MB at K-values of 9.</div></div>","PeriodicalId":10616,"journal":{"name":"Computational Biology and Chemistry","volume":"115 ","pages":"Article 108363"},"PeriodicalIF":2.6000,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computational Biology and Chemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1476927125000234","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lung Cancer is regarded as a common fatal disease affecting humans throughout the entire world. Early diagnosis is vital to save the patient’s life and Computed Tomography (CT) scans are referred to as the major imaging modes but, the manual examination of a CT scan is time-consuming and results in errors. Hence, a novel system of Neuron Attention Visual Taylor Network (NAVT-Net) is developed to detect lung cancer. At first, the CT image is acquired, and then, the input image is filtered based on homomorphic filtering. Then, the lung nodule is segmented using the Dual-Branch-UNet (DB-UNet). Later, the image augmentation is achieved by resizing, flipping, as well as rotation. Next, the shape-based features are extracted and subjected to the last stage of lung cancer detection, which is done by the NAVT-Net system that is established on the basis of Neuron Attention Stage-by-Stage Network (NASNet), Visual Geometry Group-16 (VGG16), and Taylor series. Hence, the experimental results of the developed NAVT-Net system achieved high values of 92.176 % accuracy, 93.997 % of True Positive Rate (TPR), 92.189 % of True Negative Rate (TNR), F1-score of 90.999 %, and precision of 91.998 %, computational time, and memory usage of 37.879 s, and 41.100MB at K-values of 9.
期刊介绍:
Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered.
Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered.
Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.