Jyoti Sharma, Pooja Dutta, Abhijit Sau, Tarun K. Panda
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引用次数: 0
Abstract
We report a direct and efficient methodology for the hydroboration of aliphatic and aryl nitro compounds using amidophosphine-borane {(C6H5)CH2N(PPh)2(BH3)2} in the presence of iron(II) chloride as a catalyst under mild conditions to form primary amines after hydrolysis. Solid amidophosphine-boranes are user-friendly and readily synthesized, revealing remarkable reducing properties toward a comprehensive range of nitro compounds. The scalability of the present approach is defined by performing gram-scale reactions and synthesis of different pharmaceuticals like paracetamol and benzocaine, demonstrating the synthetic applicability of the current strategy.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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