{"title":"Ibuprofen prevents the conjugative transfer of plasmid-mediated antimicrobial resistance genes.","authors":"Guangfen Zhang, Chunli Li, Xiaofan Li, Yuanyuan Li, Yunbing Li, Xiangkun Zeng, Chen Xu, Shuyan Wu, Ning Dong","doi":"10.1016/j.jgar.2025.01.012","DOIUrl":null,"url":null,"abstract":"<p><p>Refractory infections caused by multidrug-resistant bacteria (MDRB) pose a significant threat to public health. We reported ibuprofen inhibited the conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, bla<sub>NDM</sub>, bla<sub>KPC</sub>, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggested ibuprofen reduced ATP production and inhibited conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of MDR, opening new therapeutic avenues to combat MDRB.</p>","PeriodicalId":15936,"journal":{"name":"Journal of global antimicrobial resistance","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of global antimicrobial resistance","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jgar.2025.01.012","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Refractory infections caused by multidrug-resistant bacteria (MDRB) pose a significant threat to public health. We reported ibuprofen inhibited the conjugation of the RP4 plasmid and plasmids from clinical strains carrying different resistance genes including mcr-1, blaNDM, blaKPC, tet(X4), and tmexCD1-toprJ1. Mechanistic studies suggested ibuprofen reduced ATP production and inhibited conjugation-related genes. The inhibitory effect of ibuprofen on conjugation has significant clinical implications for preventing the spread of MDR, opening new therapeutic avenues to combat MDRB.
期刊介绍：
The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes.
JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR).
Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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