Xiao Cao , Jieyong Jia , Linyue Wu , Tianjia Huang , Mi Chen , Wen Niu , Tianzi Yang , Qin Zhou , Bo Lei , Yuncong Li
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引用次数: 0
Abstract
Objectives
Novel zinc-doped bioactive glass nanoparticles (ZnBGNs) were designed for dental adhesive to enable multifunctional properties for dentin bonding durability.
Methods
ZnBGNs were synthesized via the sol-gel template method and characterized via TEM, SEM and EDS. ZnBGNs were added from 2.5wt% to 10wt% to Adper™ Single Bond 2 adhesive (SB2). The effects of ZnBGNs on the degree of conversion, contact angle and antibacterial activity were measured. Endogenous matrix metalloproteinases (MMPs) activity, Young's modulus of the hybrid layer, microtensile bond strength and interfacial nanoleakage were investigated after 24 h and 3 months ageing in artificial saliva.
Results
ZnBGNs exhibited good monodispersity, bioactivity activity and superior antimicrobial activity. Adding no >5 wt% ZnBGNs had no adverse effects on the degree of conversion and contact angle of the SB2 Control (p > 0.05). Incorporating ZnBGNs dramatically reduced the endogenous MMPs activity, facilitated remineralization and increased the Young's modulus of the hybrid layer after 3 months ageing (p < 0.05). Dentin bond strength had 44 % loss with increased nanoleakage after 3 months of ageing for SB2 Control. However, SB2+2.5 wt% ZnBGNs showed no loss in bond strength and the least degree of nanoleakage after 3 months ageing (p < 0.05).
Conclusions
Incorporating ZnBGNs into dental adhesive systems can provide antimicrobial, anti-metalloproteinase and remineralization microenvironments, which indicates a suitable strategy to prevent the degradation of hybrid layers.
Clinical Significance
ZnBGNs with multifunctional properties will likely be used to prevent the degradation of hybrid layers, thereby extending the longevity of resin-dentin bonds.
期刊介绍：
The Journal of Dentistry has an open access mirror journal The Journal of Dentistry: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
The Journal of Dentistry is the leading international dental journal within the field of Restorative Dentistry. Placing an emphasis on publishing novel and high-quality research papers, the Journal aims to influence the practice of dentistry at clinician, research, industry and policy-maker level on an international basis.
Topics covered include the management of dental disease, periodontology, endodontology, operative dentistry, fixed and removable prosthodontics, dental biomaterials science, long-term clinical trials including epidemiology and oral health, technology transfer of new scientific instrumentation or procedures, as well as clinically relevant oral biology and translational research.
The Journal of Dentistry will publish original scientific research papers including short communications. It is also interested in publishing review articles and leaders in themed areas which will be linked to new scientific research. Conference proceedings are also welcome and expressions of interest should be communicated to the Editor.
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