{"title":"Multiomics atlas reveals molecular and genetic drivers of human ovarian aging","authors":"","doi":"10.1038/s43587-025-00821-5","DOIUrl":null,"url":null,"abstract":"Single-nuclei multiomics analyses of ovarian tissue from young and reproductively aged individuals reveal mTOR signaling as an ovary-specific aging pathway and identify functional genetic variants associated with ovarian aging. This comprehensive atlas provides insights into molecular and genetic mechanisms of ovarian aging and potential therapeutic targets for reproductive longevity.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 2","pages":"186-187"},"PeriodicalIF":19.4000,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00821-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Single-nuclei multiomics analyses of ovarian tissue from young and reproductively aged individuals reveal mTOR signaling as an ovary-specific aging pathway and identify functional genetic variants associated with ovarian aging. This comprehensive atlas provides insights into molecular and genetic mechanisms of ovarian aging and potential therapeutic targets for reproductive longevity.
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