Contact and communication: ZO-2 and the Hippo pathway.

Miranda Thomas
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Abstract

The PDZ domain-containing protein ZO-2 is defined as a tight junction (TJ) protein, but is also known to have a role in the maintenance of cellular apicobasal polarity and to function as a signalling molecule in several pathways, including the Hippo pathway. In this issue, Liu OX et al. [(2024) FEBS J, https://doi.org/10.1111/febs.17304] report how the multiple protein binding sites of ZO2 protein allow it to act as a scaffold to facilitate its signalling functions.

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含 PDZ 结构域的蛋白 ZO-2 被定义为紧密连接(TJ)蛋白,但已知它还在维持细胞顶端极性方面发挥作用,并在包括 Hippo 通路在内的几条通路中发挥信号分子的功能。本期,Liu OX 等人[(2024) FEBS J, https://doi.org/10.1111/febs.17304]报告了 ZO2 蛋白的多个蛋白结合位点如何使其充当支架以促进其信号功能。
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