Advantages of electrochemically deposited bioceramic-coating on magnesium implant for anti-corrosion and bone regeneration

IF 6.3 2区材料科学 Q2 CHEMISTRY, PHYSICAL Surfaces and Interfaces Pub Date : 2025-02-15 Epub Date: 2025-02-02 DOI:10.1016/j.surfin.2025.105936

Seo-young kim, Yu-kyoung kim, Yong-seok Jang, Min-ho Lee

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Abstract

Magnesium implants offer the advantages of biodegradability and absorbability after implantation in bone fractures. However, they cause delayed bone regeneration owing to their fast biodegradation rates.

To address this issue, we attempted to utilize the bioactivity of bioceramic coatings and anti-corrosion property by doping Zn ions onto Mg implant surfaces. Zn-doped CaP bioceramic precipitation was induced on magnesium surfaces via electrochemical deposition in a mixed electrolyte of Ca(NO₃)₂ and NH₄H₂PO₄ with varying concentrations of Zn(NO₃)₂. As a result, in an electrolyte containing a low concentration of Zn(NO₃)₂, a uniform film layer, consisting of hydroxyapatite (HA) and calcium zinc phosphate hydrate (CZPD) bioceramics, was formed with approximately 30 μm of thickness. This layer improved the corrosion resistance of the Mg surface in simulated body fluids and promoted the formation of bioactive substrates. Higher concentrations of Zn(NO₃)₂ in the electrolyte led to an enhanced corrosion resistance with increasing Ca(OH)₂ precipitation. However, corrosion products were formed instead of bioactive substrates. Therefore, it was demonstrated that appropriate Zn(NO₃)₂ addition during electrochemical deposition induced stable osteoblast attachment and uniform formation of a new bone layer, delayed biodegradation with excellent corrosion resistance, and promoted bone regeneration through the formation of bioactive substrates during implantation.

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电化学沉积生物陶瓷涂层在镁种植体防腐和骨再生中的优势

镁植入物在骨折植入后具有生物降解性和可吸收性。然而，由于它们的生物降解速度快，导致骨再生延迟。为了解决这一问题，我们试图利用生物陶瓷涂层的生物活性和抗腐蚀性能，在Mg植入体表面掺杂Zn离子。在不同浓度Zn(NO3)2的Ca(NO3)2和NH4H2PO4混合电解质中电化学沉积，在镁表面诱导出掺锌CaP生物陶瓷的沉淀。结果表明，在含低浓度Zn(NO3)2的电解液中，形成了厚度约为30 μm的由羟基磷灰石（HA）和磷酸氢锌钙（CZPD）生物陶瓷组成的均匀膜层。该层提高了Mg表面在模拟体液中的耐腐蚀性，促进了生物活性基质的形成。电解质中Zn(NO3)2浓度越高，随着Ca(OH)2析出量的增加，耐蚀性越强。然而，腐蚀产物的形成取代了生物活性底物。因此，研究表明，在电化学沉积过程中适当添加Zn(NO3)2可诱导成骨细胞稳定附着，形成均匀的新骨层，延缓生物降解，具有优异的耐腐蚀性，并通过植入过程中形成生物活性底物促进骨再生。

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来源期刊

Surfaces and Interfaces Chemistry-General Chemistry

CiteScore

8.50

自引率

6.50%

发文量

753

审稿时长

35 days

期刊介绍： The aim of the journal is to provide a respectful outlet for ''sound science'' papers in all research areas on surfaces and interfaces. We define sound science papers as papers that describe new and well-executed research, but that do not necessarily provide brand new insights or are merely a description of research results. Surfaces and Interfaces publishes research papers in all fields of surface science which may not always find the right home on first submission to our Elsevier sister journals (Applied Surface, Surface and Coatings Technology, Thin Solid Films)