Machine learning based finite element analysis for personalized prediction of pressure injury risk in patients with spinal cord injury

IF 4.8 2区 医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Computer methods and programs in biomedicine Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI:10.1016/j.cmpb.2025.108648
Ke Zhang , Yufang Chen , Chenglong Feng , Xinhao Xiang , Xiaoqing Zhang , Ying Dai , Wenxin Niu
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Abstract

Background and Objective

Patients with spinal cord injury (SCI), are prone to pressure injury (PI) in the soft tissues of buttocks. Early prediction of PI holds the potential to reduce the occurrence and progression of PI. This study proposes a machine learning model to predict soft tissue stress/strain and evaluate PI risk in SCI patients.

Methods

Based on the standard database from parametric models of buttock, the biomechanical response of soft tissues and risk factors affecting PI were analyzed. A comprehensive assessment of multiple machine-learning methods was performed to predict the risk of PI, the selected optimal model is explained locally and globally using Shapley additive explanations (SHAP).

Results

The proposed hybrid model for predicting PI consists of a backpropagation neural network and Extreme Gradient Boosting, performed the coefficient of determination (R2) of 0.977.

Conclusion

The model exhibits accurate performance which may be considered as the ideal method for predicting PI. Furthermore, it can be used with other health-monitoring equipment to improve the quality of patients with SCI or other dysfunctional diseases.
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基于机器学习的有限元分析对脊髓损伤患者压力损伤风险的个性化预测
背景与目的脊髓损伤(SCI)患者易发生臀部软组织压迫性损伤(PI)。早期预测PI有可能减少PI的发生和发展。本研究提出了一种机器学习模型来预测脊髓损伤患者的软组织应力/应变和评估PI风险。方法基于臀部参数化模型标准数据库,分析软组织生物力学反应及影响PI的危险因素。对多种机器学习方法进行综合评估以预测PI的风险,选择的最佳模型使用Shapley加性解释(SHAP)在局部和全局进行解释。结果建立的PI预测混合模型由反向传播神经网络和极端梯度增强组成,决定系数(R2)为0.977。结论该模型性能准确,可作为预测PI的理想方法。此外,它可以与其他健康监测设备一起使用,以提高脊髓损伤或其他功能障碍疾病患者的质量。
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来源期刊
Computer methods and programs in biomedicine
Computer methods and programs in biomedicine 工程技术-工程:生物医学
CiteScore
12.30
自引率
6.60%
发文量
601
审稿时长
135 days
期刊介绍: To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.
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