Synthesis and Evaluation of Neurotropic Activity of New Terahydropyridazin-3-one Derivatives

Abstract

4-Aryl-4-oxo-2-(1,2-substituted 1H-indol-3-yl)butanoic acids reacted with hydrazine to give 6-aryl-4-(1,2-substituted 1H-indol-3-yl)-2,3,4,5-tetrahydropyridazin-3-ones, whereas heterocyclization of structurally related 4-aryl-4-oxo-2-hetarylbutanoic acids under similar conditions was accompanied by elimination of the azole moiety, leading to the formation of 6-aryl-2,3-dihydropyridazin-3-ones. Study of neurotropic activity of the new tetrahydropyridazinone derivatives revealed anxiolytic effect of all compounds.