Zhen Chen, Xiang Yun, Jiaqi Tian, Fei Li, Zitong Zhang, Jiahua Meng, Ning Li, Hongying Bian, Shuyin Duan, Lin Zhang
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引用次数: 0
Abstract
Exosome-Based Nano Drug Delivery System
Macrophage-derived exosomes offer a novel approach to deliver pirfenidone (PFD) for treating silicotic pulmonary fibrosis. In article 2403227, Shuyin Duan, Lin Zhang, and co-workers demonstrate that PFD-loaded exosomes effectively inhibit fibroblast activation and reduce lung fibrosis in a mouse model of silicosis, while potentially mitigating systemic side effects. The cover illustrates lung-originating macrophages secreting exosomes engineered to encapsulate PFD for targeted pulmonary delivery.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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