Pseudo-3D Topological Alignments Regulate Mechanotransduction and Maturation of Smooth Muscle Cells (Adv. Healthcare Mater. 4/2025)

Abstract

Topological Cues Affect Smooth Muscle Cell

This cover uses the “Three Little Pigs” analogy to explain how topological cues affect smooth muscle cell mechanotransduction and maturation. On flat surfaces, cells build simple “straw houses,” representing less mature growth, while on complex terrains, they construct “brick houses,” signifying enhanced maturity. The pseudo-3D muscle mimic model highlights how environmental structure influences mechanotransduction and muscle cell phenotype. More details can be found in article 2402492 by Han-Jun Kim, Junmin Lee, and co-workers.