Associations Between COVID-19 Vaccination Status and Persistent Symptoms: A Prospective Study of Reproductive-Age Women

IF 2.1 4区医学 Q3 HEALTH CARE SCIENCES & SERVICES Journal of evaluation in clinical practice Pub Date : 2025-02-07 DOI:10.1111/jep.70005

Ilkin Seda Can Caglayan, Gulbahtiyar Demirel, Ceren Eda Can

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Abstract

Objective

The present study was conducted to determine the relationship between prolonged complaints of women who had COVID-19 infection and whose symptoms persisted and their vaccination status against COVID-19.

Methods

This prospective observational study consisted of three groups [The Unvaccinated Group (Control Group: 89), the BioNTech Vaccine Group (114 people), and the Sinovac Vaccine Group (84 people)]. In this study, which included 287 women, prolonged COVID-19 symptoms in their spouses were also questioned. Information was obtained from the participants in the form of questions and answers under outpatient clinical conditions 2 months after their recovery. Women between the ages of 18–45 who had regular menstrual periods in the last 6 months before the pandemic, those whose COVID-19 test was negative and those who received a single dose of vaccine in the vaccinated group were included in the study.

Results

The rates of loss of taste and prolonged symptoms of high fever in Sinovac-vaccinated participants were lower than in the other groups in the present study (p < 0.05). A total of 40.5% of those who were vaccinated with Sinovac after COVID-19 had a menstrual cycle length of every 28–40 days, which was higher than the percentage of participants in other groups, and 40.5% of those in this group did not have menstrual pain. Additionally, the menstrual period length of 62.3% of the participants who received the BioNTech vaccine increased (p < 0.05). This increase is higher than the participants in the other group.

Conclusion

The study indicated that certain prolonged symptoms of COVID-19 infection were less common among participants vaccinated with Sinovac. In this group, the menstrual cycle length increased, while menstrual pain decreased.

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来源期刊

Journal of evaluation in clinical practice 医学-卫生保健

CiteScore

4.80

自引率

4.20%

发文量

143

审稿时长

3-8 weeks

期刊介绍： The Journal of Evaluation in Clinical Practice aims to promote the evaluation and development of clinical practice across medicine, nursing and the allied health professions. All aspects of health services research and public health policy analysis and debate are of interest to the Journal whether studied from a population-based or individual patient-centred perspective. Of particular interest to the Journal are submissions on all aspects of clinical effectiveness and efficiency including evidence-based medicine, clinical practice guidelines, clinical decision making, clinical services organisation, implementation and delivery, health economic evaluation, health process and outcome measurement and new or improved methods (conceptual and statistical) for systematic inquiry into clinical practice. Papers may take a classical quantitative or qualitative approach to investigation (or may utilise both techniques) or may take the form of learned essays, structured/systematic reviews and critiques.