EXPRESSION OF CONCERN: Bcl-2 Overexpression in Human Melanoma Cells Increases Angiogenesis Through VEGF mRNA Stabilization and HIF-1-mediated Transcriptional Activity

Abstract

EXPRESSION OF CONCERN: A. Iervolino, D. Trisciuoglio, D. Ribatti, A. Candiloro, A. Biroccio, G. Zupi, D. Del Bufalo, “Bcl-2 Overexpression in Human Melanoma Cells Increases Angiogenesis Through VEGF mRNA Stabilization and HIF-1-mediated Transcriptional Activity,” The FASEB Journal 16, no. 11 (2002): 1453-1455, https://doi.org/10.1096/fj.02-0122fje.

This Expression of Concern is for the above article, published online on July 01, 2002, in Wiley Online Library (http://onlinelibrary.wiley.com/), and has been issued by agreement between the journal Editor-in-Chief, Loren E. Wold; the Federation of American Societies for Experimental Biology; and Wiley Periodicals LLC. A third party reported concerns of duplication and manipulation in Figure 1, and splicing and duplication in Figures 2B and 5A. These concerns were confirmed by the journal and publisher. Author D. Del Bufalo responded to an inquiry by the journal on behalf of the authors, but the authors were not able to supply original data due to the length of time that has elapsed since publication. The Expression of Concern has been agreed on because the evidence of image manipulation and duplication calls into question the validity of the data in Figures 1, 2, and 5, which cannot be confirmed due to the lack of original data. Author D. Del Bufalo disagrees with the Expression of Concern. All other authors did not respond to our notice regarding the Expression of Concern.