Comparing the Risk of Epilepsy in Patients With Simple Congenital Heart Diseases: A Prospective Cohort Study

IF 5 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2025-02-07 DOI:10.1111/cns.70230

Lei Chen, Zuyao Yang, Shuming Ji, Tingting Song, Hua Li, Yusha Tang, Yucheng Chen, Yajiao Li

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Abstract

Aims

Simple congenital heart diseases (CHD) are associated with various central nervous system diseases, including epilepsy. This study aimed to compare the risk of epilepsy in patients with different types of simple CHD.

Methods

In this prospective cohort study, from January 2008 to June 2022, patients with atrial septal defect (ASD), patent foramen ovale (PFO), ventricular septal defect (VSD), and patent ductus arteriosus (PDA) were recruited at the Registration Center of CHD in West China Hospital. Follow-up was conducted yearly until the diagnosis of epilepsy, loss to follow-up, or end of study. The outcomes included a comparison of epilepsy incidence according to different simple CHD types and a risk assessment of developing epilepsy. Multivariable Poisson regression was performed to adjusted factors of demographics and disease history.

Results

Of 10,914 patients who met the inclusion criteria, 108 were diagnosed with epilepsy at an average follow-up of 2.19 years. Epilepsy incidence in patients with PFO, VSD, PDA, and ASD was 8.58/1000, 4.85/1000, 3.98/1000, and 2.63/1000 person-years, respectively. Compared with ASD patients (reference group), the risk ratios (95% confidence intervals) in patients with PFO, VSD, and PDA were 3.28 (2.00–5.43), 1.47 (0.79–2.68), and 1.46 (0.70–2.82), respectively. Subgroup analyses determined that patients with simple CHD who underwent CHD surgery demonstrated a lower risk of epilepsy than those who did not.

Conclusion

Among the major types of simple CHD, PFO was associated with a significantly higher risk of epilepsy, while the risk was reduced in those who underwent PFO closure procedures.

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比较单纯性先天性心脏病患者癫痫的风险：一项前瞻性队列研究

目的单纯性先天性心脏病（CHD）与包括癫痫在内的多种中枢神经系统疾病有关。本研究旨在比较不同类型单纯性冠心病患者发生癫痫的风险。方法2008年1月至2022年6月，在华西医院冠心病挂号中心招募房间隔缺损（ASD）、卵圆孔未闭（PFO）、室间隔缺损（VSD）、动脉导管未闭（PDA）患者。随访每年进行一次，直到诊断为癫痫，失去随访或研究结束。结果包括不同单纯性冠心病类型的癫痫发病率的比较和发生癫痫的风险评估。采用多变量泊松回归对人口统计学和病史因素进行校正。结果10914例符合纳入标准的患者中，108例被诊断为癫痫，平均随访2.19年。PFO、VSD、PDA、ASD患者的癫痫发病率分别为8.58/1000、4.85/1000、3.98/1000、2.63/1000人年。与ASD患者（对照组）相比，PFO、VSD和PDA患者的风险比（95%可信区间）分别为3.28（2.00-5.43）、1.47（0.79-2.68）和1.46（0.70-2.82）。亚组分析表明，接受冠心病手术的单纯性冠心病患者癫痫发作的风险低于未接受手术的患者。结论：在主要类型的单纯性冠心病中，PFO与癫痫的风险显著升高相关，而接受PFO关闭手术的患者癫痫风险降低。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.