Emerging Roles of Non-coding RNAs in Cardiovascular Pathophysiology.

IF 4.1 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS American journal of physiology. Heart and circulatory physiology Pub Date : 2025-02-07 DOI:10.1152/ajpheart.00681.2024

Malak Abbas, Amadou Gaye

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引用次数: 0

Abstract

This review comprehensively examines the diverse roles of non-coding RNAs (ncRNAs) in the pathogenesis and treatment of cardiovascular disease (CVD), focusing on microRNA (miRNA), long non-coding RNA (lncRNA), piwi-interacting RNA (piRNA), small interfering RNA (siRNA), circular RNA (circRNA), and vesicle-associated RNAs. These ncRNAs are integral regulators of key cellular processes, including gene expression, inflammation, and fibrosis, and they hold great potential as both diagnostic biomarkers and therapeutic targets. The review highlights novel insights into how these RNA species, particularly miRNAs, lncRNAs, and piRNAs, contribute to various CVDs such as hypertension, atherosclerosis, and myocardial infarction. Additionally, it explores the emerging role of extracellular vesicles (EVs) in intercellular communication and their therapeutic potential in cardiovascular health. The review underscores the need for continued research into ncRNAs and RNA-based therapies, with a focus on advancing delivery systems and expanding personalized medicine approaches to improve cardiovascular outcomes.

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来源期刊

American journal of physiology. Heart and circulatory physiology 医学-生理学

CiteScore

9.60

自引率

10.40%

发文量

202

审稿时长

2-4 weeks

期刊介绍： The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.