Soukaina Sabir, Odelaisy León-Triana, Sergio Serrano, Roberto Barrio, Victor M Pérez-García
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引用次数: 0
Abstract
CAR T-cell therapies have demonstrated significant success in treating B-cell leukemia in children and young adults. However, their effectiveness in treating B-cell lymphomas has been limited in comparison to leukemia. In this paper we present a mathematical model that elucidates the dynamics of diffuse large B-cell lymphoma and CAR T-cells in a lymph node. The mathematical model aids in understanding the complex interplay between the cell populations involved and proposes ways to identify potential underlying dynamical causes of treatment failure. We also study the phenomenon of immunosuppression induced by tumor cells and theoretically demonstrate its impact on cell dynamics. Through the examination of various response scenarios, we underscore the significance of product characteristics in treatment outcomes.
CAR - t细胞疗法在治疗儿童和年轻人的b细胞白血病方面取得了显著的成功。然而，与白血病相比，它们治疗b细胞淋巴瘤的效果有限。在本文中，我们提出了一个数学模型，阐明了弥漫性大b细胞淋巴瘤和CAR - t细胞在淋巴结中的动力学。该数学模型有助于理解所涉及的细胞群之间复杂的相互作用，并提出了识别治疗失败的潜在潜在动力学原因的方法。我们还研究了肿瘤细胞诱导的免疫抑制现象，并从理论上论证了其对细胞动力学的影响。通过对各种反应情景的检查，我们强调了产品特性在治疗结果中的重要性。
期刊介绍：
The Bulletin of Mathematical Biology, the official journal of the Society for Mathematical Biology, disseminates original research findings and other information relevant to the interface of biology and the mathematical sciences. Contributions should have relevance to both fields. In order to accommodate the broad scope of new developments, the journal accepts a variety of contributions, including:
Original research articles focused on new biological insights gained with the help of tools from the mathematical sciences or new mathematical tools and methods with demonstrated applicability to biological investigations
Research in mathematical biology education
Reviews
Commentaries
Perspectives, and contributions that discuss issues important to the profession
All contributions are peer-reviewed.
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