{"title":"Radiomics and molecular analysis: Bridging the gap for predicting hepatocellular carcinoma prognosis.","authors":"Chun-Han Cheng, Wen-Rui Hao, Tzu-Hurng Cheng","doi":"10.12998/wjcc.v13.i4.98550","DOIUrl":null,"url":null,"abstract":"<p><p>This editorial examines a recent study that used radiomics based on computed tomography (CT) to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2 (<i>EZH2</i>) and its correlation with the survival of patients with hepatocellular carcinoma (HCC). By integrating radiomics with molecular analysis, the study presented a strategy for accurately predicting the expression of <i>EZH2</i> from CT scans. The findings demonstrated a strong link between the radiomics model, <i>EZH2</i> expression, and patient prognosis. This noninvasive approach provides valuable insights into the therapeutic management of HCC.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 4","pages":"98550"},"PeriodicalIF":1.0000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586797/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Clinical Cases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12998/wjcc.v13.i4.98550","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
This editorial examines a recent study that used radiomics based on computed tomography (CT) to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2 (EZH2) and its correlation with the survival of patients with hepatocellular carcinoma (HCC). By integrating radiomics with molecular analysis, the study presented a strategy for accurately predicting the expression of EZH2 from CT scans. The findings demonstrated a strong link between the radiomics model, EZH2 expression, and patient prognosis. This noninvasive approach provides valuable insights into the therapeutic management of HCC.
期刊介绍：
The World Journal of Clinical Cases (WJCC) is a high-quality, peer reviewed, open-access journal. The primary task of WJCC is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of clinical cases. In order to promote productive academic communication, the peer review process for the WJCC is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCC are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in clinical cases.
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