Will the New Lancet Commission Classification of Obesity Only Mystify and Complicate Things in Paediatric Clinics?

IF 2.1 4区 医学 Q1 PEDIATRICS Acta Paediatrica Pub Date : 2025-02-07 DOI:10.1111/apa.70005
Annika Janson
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The first option is that people who used to fulfill the simple body mass index (BMI) criteria for overweight or obesity would no longer receive a diagnosis. The second is that, after careful consideration, they could meet the definitions for diagnoses of pre-clinical obesity or clinical obesity. Overweight, a general term that has often been used to describe both overweight and obesity in daily speech, but has lacked the status of a diagnosis, seems obsolete.</p><p>The 42-page Commission's report will now challenge the printers in many obesity clinics. Having read it, I can summarise it as follows. It is not enough with a high BMI to be diagnosed with clinical obesity. Measurements that indicate increased body fat will be needed for a diagnosis, such as the patient's fat percentage, waist circumference, waist-to-height ratio or waist-to-hip ratio. In addition, symptoms that indicate problems, such as pain or affected blood tests, are needed. With all due respect to the Commission, the operational definitions are unclear for many of the 18 criteria for adults and 13 for children. Just consider this criterion for paediatric patients: ‘cluster of hyperglycemia/glucose intolerance with abnormal lipid profile (high triglyceride levels or high LDL cholesterol or low HDL cholesterol)’. Note the word ‘with’ which tells us that glucose intolerance without lipid disturbances or even manifest type 2 diabetes is not included as a criterion. Similarly, a criterion like polycystic ovary syndrome is hard to define in girls. Another issue is that the prerequisites for diagnosing clinical obesity, namely body fat percentage or waist circumference, do not have clear and generally accepted cut-offs for children [<span>2</span>].</p><p>Those who like an academic battle could go on debating diagnostics, degrees and definitions forever, but that takes a lot of human power away from treating the patients we see in our clinics.</p><p>The coverage in the general, non-medical media has been respectful, but two well-respected UK titles have raised concerns. <i>The Guardian</i> remarked that the health challenges of curbing obesity remain [<span>3</span>]. Meanwhile, <i>The Economist</i> saw the need to decide ‘who is sick and who is not’, [<span>4</span>] suggesting that there needs to be a distinction in the era of new and effective, but costly, anti-obesity drugs.</p><p>The current definitions of overweight and obesity cover about a fifth of the children in Sweden [<span>5</span>] and a change in the diagnostic criteria will clearly matter. Today, we use the cut-offs that are visible in all growth charts to determine whether a child has a normal weight for their age and sex. These help us to diagnose overweight or obesity, and if needed, divide the latter into obesity grades 1–3 [<span>6</span>].</p><p>Using BMI charts to diagnose obesity is easy to do in clinics and it is also easy to teach. It takes 2 s to determine whether a child is above the cut-off points for overweight or obesity, but it takes skill and experience to communicate the diagnosis to the child and family.</p><p>We make the diagnosis and take it from there. Many children with obesity are well, while others are more affected. But we make sure that we stress the positives and appreciate all signs of good health. We determine whether the child has uncomplicated obesity or whether complications are already present. And then we start to try and change the course of weight development and prevent the progression into more severe degrees of obesity and more complications. Health care providers will refer children with obesity grade 2 or 3, or complications, to higher levels of care for more intense treatments.</p><p>Obesity hampers a child's ability to move, play, sleep and perform at school. Many children with obesity have concomitant diseases that make things more complex, such as neuropsychiatric comorbidities. Many have psychosocial challenges. These appear to be missing from the list of criteria produced by the Commission and they are often the most important aspects.</p><p>Most children and adolescents with obesity remain with obesity during their adult years [<span>7</span>]. We also know that two children of the same height, sex, and age can have different BMIs and these can largely be explained by variations in the amount of body fat. Muscle growth is limited before puberty and cannot explain a high BMI. We try hard to cater to patients' individual needs and reduce stigma of all kinds.</p><p>It is interesting that Putri et al. published a critical study in <i>JAMA Paediatrics</i> just after the Lancet Commission paper appeared. The study, which used data from the Swedish Childhood Obesity Treatment Register, illustrates the benefits of diagnosing obesity using established methods. It showed that children who had effective treatment for obesity in childhood had reduced risks of mortality and lower risks for diseases like type 2 diabetes in adulthood, unlike children for whom treatment was not as effective [<span>8</span>]. An editorial on the paper, by Epstein et al., concluded that the study was probably the first to demonstrate the impact of paediatric treatment for obesity on cardiometabolic disease and mortality in young adulthood [<span>9</span>].</p><p>Obesity per se can safely remain a diagnosis for children, and it should entitle them and their families to the care they need to help them preserve their future health. We need a straightforward and relevant classification that can be easily communicated to parents and other stakeholders. Instead of battling over criteria, we need to focus our attention on disseminating and following the most useful guidelines [<span>10</span>].</p><p>It would be great to agree on a global reference on overweight and obesity, as there are several international and national references that have been used to develop the different BMI charts used across the world. Having different references definitively makes international comparisons difficult. However, I believe there is no need to mystify and complicate things further for clinicians dealing with children's weight issues. While I applaud the scrutiny that the Lancet Commission experts have paid to this subject, I would rather stick to my present BMI growth charts for diagnosis.</p><p><b>Annika Janson:</b> conceptualization, writing – original draft.</p><p>The author declares no conflicts of interest.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":"114 5","pages":"788-789"},"PeriodicalIF":2.1000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apa.70005","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Paediatrica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/apa.70005","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
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Abstract

In January 2025, a new classification of obesity was published in the Lancet Diabetes & Endocrinology [1]. It was developed by The Lancet Commission on the Definition and Diagnosis of Clinical Obesity, which comprised more than 50 researchers and experts in the field. The contributors should be praised for their enormous efforts and for including people living with obesity to ensure that the new classification included perspectives from patients. However, despite the appealing graphics that aim to explain the new criteria, the approach has left even insightful readers with doubts.

So what does the new classification say? The first option is that people who used to fulfill the simple body mass index (BMI) criteria for overweight or obesity would no longer receive a diagnosis. The second is that, after careful consideration, they could meet the definitions for diagnoses of pre-clinical obesity or clinical obesity. Overweight, a general term that has often been used to describe both overweight and obesity in daily speech, but has lacked the status of a diagnosis, seems obsolete.

The 42-page Commission's report will now challenge the printers in many obesity clinics. Having read it, I can summarise it as follows. It is not enough with a high BMI to be diagnosed with clinical obesity. Measurements that indicate increased body fat will be needed for a diagnosis, such as the patient's fat percentage, waist circumference, waist-to-height ratio or waist-to-hip ratio. In addition, symptoms that indicate problems, such as pain or affected blood tests, are needed. With all due respect to the Commission, the operational definitions are unclear for many of the 18 criteria for adults and 13 for children. Just consider this criterion for paediatric patients: ‘cluster of hyperglycemia/glucose intolerance with abnormal lipid profile (high triglyceride levels or high LDL cholesterol or low HDL cholesterol)’. Note the word ‘with’ which tells us that glucose intolerance without lipid disturbances or even manifest type 2 diabetes is not included as a criterion. Similarly, a criterion like polycystic ovary syndrome is hard to define in girls. Another issue is that the prerequisites for diagnosing clinical obesity, namely body fat percentage or waist circumference, do not have clear and generally accepted cut-offs for children [2].

Those who like an academic battle could go on debating diagnostics, degrees and definitions forever, but that takes a lot of human power away from treating the patients we see in our clinics.

The coverage in the general, non-medical media has been respectful, but two well-respected UK titles have raised concerns. The Guardian remarked that the health challenges of curbing obesity remain [3]. Meanwhile, The Economist saw the need to decide ‘who is sick and who is not’, [4] suggesting that there needs to be a distinction in the era of new and effective, but costly, anti-obesity drugs.

The current definitions of overweight and obesity cover about a fifth of the children in Sweden [5] and a change in the diagnostic criteria will clearly matter. Today, we use the cut-offs that are visible in all growth charts to determine whether a child has a normal weight for their age and sex. These help us to diagnose overweight or obesity, and if needed, divide the latter into obesity grades 1–3 [6].

Using BMI charts to diagnose obesity is easy to do in clinics and it is also easy to teach. It takes 2 s to determine whether a child is above the cut-off points for overweight or obesity, but it takes skill and experience to communicate the diagnosis to the child and family.

We make the diagnosis and take it from there. Many children with obesity are well, while others are more affected. But we make sure that we stress the positives and appreciate all signs of good health. We determine whether the child has uncomplicated obesity or whether complications are already present. And then we start to try and change the course of weight development and prevent the progression into more severe degrees of obesity and more complications. Health care providers will refer children with obesity grade 2 or 3, or complications, to higher levels of care for more intense treatments.

Obesity hampers a child's ability to move, play, sleep and perform at school. Many children with obesity have concomitant diseases that make things more complex, such as neuropsychiatric comorbidities. Many have psychosocial challenges. These appear to be missing from the list of criteria produced by the Commission and they are often the most important aspects.

Most children and adolescents with obesity remain with obesity during their adult years [7]. We also know that two children of the same height, sex, and age can have different BMIs and these can largely be explained by variations in the amount of body fat. Muscle growth is limited before puberty and cannot explain a high BMI. We try hard to cater to patients' individual needs and reduce stigma of all kinds.

It is interesting that Putri et al. published a critical study in JAMA Paediatrics just after the Lancet Commission paper appeared. The study, which used data from the Swedish Childhood Obesity Treatment Register, illustrates the benefits of diagnosing obesity using established methods. It showed that children who had effective treatment for obesity in childhood had reduced risks of mortality and lower risks for diseases like type 2 diabetes in adulthood, unlike children for whom treatment was not as effective [8]. An editorial on the paper, by Epstein et al., concluded that the study was probably the first to demonstrate the impact of paediatric treatment for obesity on cardiometabolic disease and mortality in young adulthood [9].

Obesity per se can safely remain a diagnosis for children, and it should entitle them and their families to the care they need to help them preserve their future health. We need a straightforward and relevant classification that can be easily communicated to parents and other stakeholders. Instead of battling over criteria, we need to focus our attention on disseminating and following the most useful guidelines [10].

It would be great to agree on a global reference on overweight and obesity, as there are several international and national references that have been used to develop the different BMI charts used across the world. Having different references definitively makes international comparisons difficult. However, I believe there is no need to mystify and complicate things further for clinicians dealing with children's weight issues. While I applaud the scrutiny that the Lancet Commission experts have paid to this subject, I would rather stick to my present BMI growth charts for diagnosis.

Annika Janson: conceptualization, writing – original draft.

The author declares no conflicts of interest.

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新的柳叶刀委员会肥胖分类只会使儿科诊所的事情变得神秘和复杂吗?
2025年1月,一种新的肥胖分类发表在《柳叶刀糖尿病》杂志上。内分泌学[1]。它是由《柳叶刀》临床肥胖定义和诊断委员会开发的,该委员会由该领域的50多名研究人员和专家组成。贡献者的巨大努力和纳入肥胖患者以确保新的分类包括患者的观点,应该受到赞扬。然而,尽管这些吸引人的图表旨在解释新标准,但这种方法甚至让有洞察力的读者产生了怀疑。那么新的分类说明了什么?第一种选择是,过去符合简单体重指数(BMI)超重或肥胖标准的人将不再接受诊断。二是经过仔细考虑,符合临床前肥胖或临床肥胖的诊断定义。超重,一个在日常用语中经常用来描述超重和肥胖的通用术语,但缺乏诊断的地位,似乎已经过时了。这份42页的委员会报告将挑战许多肥胖诊所的打印机。读过之后,我可以总结如下。仅仅有高BMI是不足以被诊断为临床肥胖的。诊断时需要测量显示体脂增加的数据,如患者的脂肪百分比、腰围、腰高比或腰臀比。此外,还需要显示问题的症状,如疼痛或受影响的血液检查。在充分尊重委员会的情况下,在成人的18项标准和儿童的13项标准中,许多标准的业务定义并不明确。只要考虑一下儿科患者的标准:“高血糖/葡萄糖耐受不良伴异常血脂(高甘油三酯水平或高LDL胆固醇或低HDL胆固醇)”。注意“with”这个词,它告诉我们,没有脂质紊乱甚至明显的2型糖尿病的葡萄糖耐受不包括在标准之内。同样,像多囊卵巢综合征这样的标准在女孩身上也很难定义。另一个问题是,诊断临床肥胖的先决条件,即体脂率或腰围,对儿童体重没有明确和普遍接受的界限。那些喜欢学术斗争的人可以永远争论诊断、学位和定义,但这会让我们在治疗诊所里看到的病人时失去很多人力。一般来说,非医疗媒体的报道是尊重的,但两家备受尊敬的英国报纸提出了担忧。《卫报》评论说,控制肥胖的健康挑战仍然很大。与此同时,《经济学人》认为有必要确定“谁生病了,谁没有病”,b[4]认为,在新的、有效的、但昂贵的抗肥胖药物时代,需要区分开来。目前对超重和肥胖的定义覆盖了瑞典约五分之一的儿童,因此诊断标准的改变显然很重要。今天,我们使用在所有生长图表中可见的截止值来确定一个孩子的年龄和性别是否正常。这些帮助我们诊断超重或肥胖,如果需要的话,将后者分为1-3级肥胖。使用BMI图表诊断肥胖在诊所很容易做到,也很容易教。确定一个孩子是否超过超重或肥胖的分界点需要20秒,但将诊断结果传达给孩子和家人则需要技巧和经验。我们做出诊断,然后采取行动。许多肥胖儿童都很健康,而另一些则受到更大的影响。但我们一定要强调积极的一面,欣赏所有健康的迹象。我们确定孩子是否患有无并发症的肥胖或是否已经存在并发症。然后我们开始尝试改变体重发展的过程,防止发展成更严重的肥胖和更多的并发症。医疗保健提供者会将患有2级或3级肥胖或并发症的儿童转介到更高水平的护理中进行更强烈的治疗。肥胖会影响孩子的活动、玩耍、睡眠和在学校的表现。许多肥胖儿童还伴有其他疾病,比如神经精神疾病,这让事情变得更加复杂。许多人都有心理挑战。委员会编制的标准清单中似乎没有这些,而它们往往是最重要的方面。大多数患有肥胖症的儿童和青少年在成年后仍然患有肥胖症。我们还知道,身高、性别和年龄相同的两个孩子可能有不同的bmi,这在很大程度上可以用体脂量的差异来解释。在青春期之前,肌肉的生长是有限的,这不能解释高BMI。我们努力满足患者的个性化需求,减少各种耻辱感。 有趣的是,就在《柳叶刀》委员会的论文发表后不久,Putri等人在《美国医学会儿科杂志》上发表了一项重要研究。这项研究使用了瑞典儿童肥胖治疗登记的数据,说明了使用既定方法诊断肥胖的好处。研究表明,儿童时期接受过有效治疗的肥胖儿童,其死亡风险和成年后患2型糖尿病等疾病的风险都较低,这与治疗效果不太好的儿童不同。Epstein等人在论文上的一篇社论中总结说,这项研究可能是第一个证明儿科治疗肥胖对心脏代谢疾病和青年死亡率影响的研究[10]。肥胖本身可以安全地作为儿童的一种诊断,它应该使儿童及其家人有权获得所需的护理,以帮助他们保持未来的健康。我们需要一个直接和相关的分类,可以很容易地传达给家长和其他利益相关者。我们需要把注意力集中在传播和遵循最有用的指导方针上,而不是在标准上进行斗争。如果能就超重和肥胖的全球参考标准达成一致,那就太好了,因为已经有几个国际和国家的参考标准被用来制定世界各地使用的不同BMI图表。有不同的参考文献肯定会使国际比较变得困难。然而,我认为没有必要让临床医生处理儿童体重问题变得更加神秘和复杂。虽然我赞赏《柳叶刀》委员会(Lancet Commission)的专家们对这个问题进行的仔细审查,但我宁愿坚持使用我目前的BMI增长图表来进行诊断。安妮卡·詹森:构思,写作-原稿。作者声明无利益冲突。
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来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
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