Evaluation of 18F-FDG absorbed dose ratios in percent in adult and pediatric reference phantoms using DoseCalcs Monte Carlo platform

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR Applied Radiation and Isotopes Pub Date : 2025-02-08 DOI:10.1016/j.apradiso.2025.111705

Tarik El Ghalbzouri , Tarek El Bardouni , Jaafar El Bakkali , Hicham Satti , Abdelhamid Nouayti , Iman Berriban , Randa Yerrou , Assia Arectout , Maryam Hadouachi

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Abstract

This study investigates the field of radiation exposure in nuclear medicine, which might have implications for exposure to ionizing radiation in pediatric cases. To demonstrate the difference in radiosensitivity between younger patients and adults and to highlight the need for individualized radiation protection procedures when investigating medical imaging and therapy, this study examines the absorbed dose ratios in percent (ADR%) for ¹⁸F-FDG. This parameter is an important indicator, illustrating the percentage of radiation dose absorbed by specific organs/tissues concerning the emitted radiation from different body regions.

The methodology involves calculating ADR% in twelve voxel-based models for adults, children, and newborns, as referenced by International Commission on Radiological Protection (ICRP) Publications 110 and 143. The simulations used the ¹⁸F positron spectrum from ICRP Publication 107 and Livermore models. These simulations were performed using the DoseCalcs Monte Carlo platform.

We have calculated the S-values and ADR% using the DoseCalcs simulations of the ¹⁸F positrons and provided a comprehensive dataset of ADR% results. This dataset evaluates the impact of anatomical variation on absorbed dose in target regions. It consists of 141 target regions and 8 different source regions.

Significant differences in radiosensitivity were observed in ADR% values among various source–target combinations for each age and sex group. The self-irradiation ADR% reaches up to 95%, while the cross-irradiation ADR% varies, ranging approximately from 0.1% to 12%, depending on the mass of the target organ, the distance between it and the source organ, and the chemical composition of these organs. Also, the variations observed across different age and sex phantoms highlight the importance of personalized internal dosimetry, especially for pediatric cases with heightened radiosensitivity. Healthcare practitioners can use the dataset of ADR% values as the first stage to illustrate variability and optimize nuclear medicine imaging with ¹⁸F-FDG while reducing radiation risks.

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使用DoseCalcs蒙特卡罗平台评估成人和儿童参考幻影中18F-FDG的吸收剂量比（以百分比为单位）

本研究调查了核医学中的辐射暴露领域，这可能对儿童电离辐射暴露有影响。为了证明年轻患者和成人之间放射敏感性的差异，并强调在研究医学成像和治疗时需要个性化的辐射保护程序，本研究检查了18F-FDG的吸收剂量百分比（ADR%）。这个参数是一个重要的指标，说明了特定器官/组织吸收的辐射剂量与身体不同部位发出的辐射的百分比。该方法包括根据国际放射防护委员会（ICRP）出版物110和143，在成人、儿童和新生儿的12个基于体素的模型中计算ADR%。模拟使用了来自ICRP出版物107和利弗莫尔模型的18F正电子谱。这些模拟是使用DoseCalcs蒙特卡洛平台进行的。我们利用DoseCalcs对18F正电子的模拟计算了s值和ADR%，并提供了ADR%结果的综合数据集。该数据集评估了解剖变异对靶区吸收剂量的影响。它由141个目标区域和8个不同的源区域组成。在不同年龄和性别组的不同源靶组合中，观察到放射敏感性的ADR%值有显著差异。自照射ADR%可达95%，而交叉照射ADR%根据靶器官的质量、与源器官的距离以及靶器官的化学成分的不同，变化范围约为0.1% ~ 12%。此外，在不同年龄和性别的幻影中观察到的变化强调了个性化内部剂量测定的重要性，特别是对于放射敏感性较高的儿科病例。医疗从业人员可以使用ADR%值数据集作为第一阶段，以说明变变性和优化核医学成像18F-FDG，同时降低辐射风险。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.