MAIT cells protect against sterile lung injury.

IF 6.9 1区生物学 Q1 CELL BIOLOGY Cell reports Pub Date : 2025-02-25 Epub Date: 2025-02-06 DOI:10.1016/j.celrep.2025.115275

Xiawei Zhang, Shuailin Li, Wojciech Lason, Maria Greco, Paul Klenerman, Timothy S C Hinks

引用次数: 0

Abstract

Mucosal-associated invariant T (MAIT) cells, the most abundant unconventional T cells in the lung, can exhibit a wide range of functional responses to different triggers via their T cell receptor (TCR) and/or cytokines. Their role, especially in sterile lung injury, is unknown. Using single-cell RNA sequencing (scRNA-seq), spectral analysis, and adoptive transfer in a bleomycin-induced sterile lung injury, we found that bleomycin activates murine pulmonary MAIT cells and is associated with a protective role against bleomycin-induced lung injury. MAIT cells drive the accumulation of type 1 conventional dendritic cells (cDC1s), limiting tissue damage in a DNGR-1-dependent manner. Human scRNA-seq data revealed that MAIT cells were activated, with increased cDC populations in idiopathic pulmonary fibrosis patients. Thus, MAIT cells enhance defense against sterile lung injury by fostering cDC1-driven anti-fibrotic pathways.

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MAIT细胞保护肺部免受无菌损伤。

mucal -associated invariant T （MAIT）细胞是肺中最丰富的非常规T细胞，可通过其T细胞受体（TCR）和/或细胞因子对不同的触发因素表现出广泛的功能反应。它们的作用，特别是在无菌肺损伤中的作用尚不清楚。通过单细胞RNA测序（scRNA-seq）、光谱分析和对博来霉素诱导的无菌肺损伤的过继性转移，我们发现博来霉素激活小鼠肺MAIT细胞，并对博来霉素诱导的肺损伤具有保护作用。MAIT细胞驱动1型常规树突状细胞（cDC1s）的积累，以dngr -1依赖的方式限制组织损伤。人类scRNA-seq数据显示，特发性肺纤维化患者的MAIT细胞被激活，cDC数量增加。因此，MAIT细胞通过培养cdc1驱动的抗纤维化途径来增强对无菌肺损伤的防御。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.