Immune Regulatory Crosstalk in Adipose Tissue Thermogenesis.

IF 5.2 2区医学 Q1 PHYSIOLOGY Comprehensive Physiology Pub Date : 2025-02-01 DOI:10.1002/cph4.70001

Ramazan Yildiz, Khatanzul Ganbold, Njeri Z R Sparman, Prashant Rajbhandari

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Abstract

Brown adipose tissue (BAT) and thermogenic beige fat within white adipose tissue (WAT), collectively known as adaptive thermogenic fat, dissipate energy as heat, offering promising therapeutic potential to combat obesity and metabolic disorders. The specific biological functions of these fat depots are determined by their unique interaction with the microenvironments, composed of immune cells, endothelial cells, pericytes, and nerve fibers. Immune cells residing in these depots play a key role in regulating energy expenditure and systemic energy homeostasis. The dynamic microenvironment of thermogenic fat depots is essential for maintaining tissue health and function. Immune cells infiltrate both BAT and beige WAT, contributing to their homeostasis and activation through intricate cellular communications. Emerging evidence underscores the importance of various immune cell populations in regulating thermogenic adipose tissue, though many remain undercharacterized. This review provides a comprehensive overview of the immune cells that regulate adaptive thermogenesis and their complex interactions within the adipose niche, highlighting their potential to influence metabolic health and contribute to therapeutic interventions for obesity and metabolic syndrome.

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脂肪组织产热中的免疫调节串扰。

棕色脂肪组织（BAT）和白色脂肪组织（WAT）中的产热米色脂肪，统称为适应性产热脂肪，以热量的形式消耗能量，为对抗肥胖和代谢紊乱提供了有希望的治疗潜力。这些脂肪库的特定生物学功能是由它们与微环境（由免疫细胞、内皮细胞、周细胞和神经纤维组成）的独特相互作用决定的。居住在这些仓库的免疫细胞在调节能量消耗和全身能量稳态中起关键作用。热源脂肪库的动态微环境对维持组织健康和功能至关重要。免疫细胞浸润BAT和米色WAT，通过复杂的细胞通讯促进它们的稳态和激活。新出现的证据强调了各种免疫细胞群在调节产热脂肪组织中的重要性，尽管许多免疫细胞群仍未被充分描述。本文综述了调节适应性产热的免疫细胞及其在脂肪生态位中的复杂相互作用，强调了它们影响代谢健康的潜力，并有助于肥胖和代谢综合征的治疗干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.