Liya Yang, Yanli Qiu, Lingyun Pan, Zijie Zhou, Yan Tan, Menghan Li, Yulong Zhu, Xiaodi Yang, Xiangwei Zheng, Weiliang Gu, Yan Ren, Houchao Tao
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引用次数: 0
Abstract
We herein present the development of a novel glycosylation protocol using glycosyl o-N-(o-methoxybenzamidoyl)-propynyl benzoates as donors, activated solely by a catalytic amount of In(OTf)3, eliminating the need for a Au(I) catalyst. This approach offers mild and orthogonal conditions, enabling glycosylation across a broad substrate scope and facilitating versatile one-pot strategies for glycan assembly. Mechanistic insights suggest that In(OTf)3 serves dual roles by being recruited to the auxiliary group through σ-coordination while activating the alkyne via π-interaction.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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