Zheqi Liu , Xiyuan Ma , Jingsheng Liu, Hao Zhang, Daping Fu
{"title":"Advances in the application of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems: A comprehensive review","authors":"Zheqi Liu , Xiyuan Ma , Jingsheng Liu, Hao Zhang, Daping Fu","doi":"10.1016/j.ijpharm.2025.125323","DOIUrl":null,"url":null,"abstract":"<div><div>Hydrogels are widely used in biomedicine because of their excellent biocompatibility, physicochemical properties, three-dimensional cross-linked polymer networks capable of absorbing and retaining a large amount of water, and various excellent properties that can be endowed to hydrogels through modification and material integration. This review focuses on the polymer compositions and applications of natural/synthetic hybrid hydrogels. Firstly, the physical and chemical crosslinking mechanisms of hybrid hydrogels with different natural/synthetic polymer combinations were discussed in depth. In addition, polymers for the preparation of natural/synthetic hybrid hydrogels and their advantages and disadvantages are widely introduced, focusing on polysaccharides, proteins, natural aromatic polymers and common synthetic polymers. Finally, this review will focus on the applications of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems. Such as bone tissue engineering, nerve tissue engineering and drug delivery.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"672 ","pages":"Article 125323"},"PeriodicalIF":5.2000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378517325001590","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Hydrogels are widely used in biomedicine because of their excellent biocompatibility, physicochemical properties, three-dimensional cross-linked polymer networks capable of absorbing and retaining a large amount of water, and various excellent properties that can be endowed to hydrogels through modification and material integration. This review focuses on the polymer compositions and applications of natural/synthetic hybrid hydrogels. Firstly, the physical and chemical crosslinking mechanisms of hybrid hydrogels with different natural/synthetic polymer combinations were discussed in depth. In addition, polymers for the preparation of natural/synthetic hybrid hydrogels and their advantages and disadvantages are widely introduced, focusing on polysaccharides, proteins, natural aromatic polymers and common synthetic polymers. Finally, this review will focus on the applications of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems. Such as bone tissue engineering, nerve tissue engineering and drug delivery.
期刊介绍：
The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
