Advances in the application of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems: A comprehensive review

IF 5.3 2区医学 Q1 PHARMACOLOGY & PHARMACY International Journal of Pharmaceutics Pub Date : 2025-02-07 DOI:10.1016/j.ijpharm.2025.125323

Zheqi Liu , Xiyuan Ma , Jingsheng Liu, Hao Zhang, Daping Fu

{"title":"Advances in the application of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems: A comprehensive review","authors":"Zheqi Liu , Xiyuan Ma , Jingsheng Liu, Hao Zhang, Daping Fu","doi":"10.1016/j.ijpharm.2025.125323","DOIUrl":null,"url":null,"abstract":"<div><div>Hydrogels are widely used in biomedicine because of their excellent biocompatibility, physicochemical properties, three-dimensional cross-linked polymer networks capable of absorbing and retaining a large amount of water, and various excellent properties that can be endowed to hydrogels through modification and material integration. This review focuses on the polymer compositions and applications of natural/synthetic hybrid hydrogels. Firstly, the physical and chemical crosslinking mechanisms of hybrid hydrogels with different natural/synthetic polymer combinations were discussed in depth. In addition, polymers for the preparation of natural/synthetic hybrid hydrogels and their advantages and disadvantages are widely introduced, focusing on polysaccharides, proteins, natural aromatic polymers and common synthetic polymers. Finally, this review will focus on the applications of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems. Such as bone tissue engineering, nerve tissue engineering and drug delivery.</div></div>","PeriodicalId":14187,"journal":{"name":"International Journal of Pharmaceutics","volume":"672 ","pages":"Article 125323"},"PeriodicalIF":5.3000,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Pharmaceutics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378517325001590","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

Abstract

Hydrogels are widely used in biomedicine because of their excellent biocompatibility, physicochemical properties, three-dimensional cross-linked polymer networks capable of absorbing and retaining a large amount of water, and various excellent properties that can be endowed to hydrogels through modification and material integration. This review focuses on the polymer compositions and applications of natural/synthetic hybrid hydrogels. Firstly, the physical and chemical crosslinking mechanisms of hybrid hydrogels with different natural/synthetic polymer combinations were discussed in depth. In addition, polymers for the preparation of natural/synthetic hybrid hydrogels and their advantages and disadvantages are widely introduced, focusing on polysaccharides, proteins, natural aromatic polymers and common synthetic polymers. Finally, this review will focus on the applications of natural/synthetic hybrid hydrogels in tissue engineering and delivery systems. Such as bone tissue engineering, nerve tissue engineering and drug delivery.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

International Journal of Pharmaceutics 医学-药学

CiteScore

10.70

自引率

8.60%

发文量

951

审稿时长

72 days

期刊介绍： The International Journal of Pharmaceutics is the third most cited journal in the "Pharmacy & Pharmacology" category out of 366 journals, being the true home for pharmaceutical scientists concerned with the physical, chemical and biological properties of devices and delivery systems for drugs, vaccines and biologicals, including their design, manufacture and evaluation. This includes evaluation of the properties of drugs, excipients such as surfactants and polymers and novel materials. The journal has special sections on pharmaceutical nanotechnology and personalized medicines, and publishes research papers, reviews, commentaries and letters to the editor as well as special issues.