Scoping review of climate drivers on maternal health: current evidence and clinical implications

Abstract

Objective

To systematically review the literature on associations between climate drivers and health outcomes among pregnant people. This review fills a gap by synthesizing evidence for a clinician audience.

Data Sources

Systematic scoping review of articles published in PubMed and clinicaltrials.gov from January 2010 through December 2023.

Study Eligibility Criteria

Empirical studies published in English-language peer-reviewed journals, assessing associations between select climate drivers and adverse maternal and birth outcomes. The review included studies examining heat, storms, sea level rise, flooding, drought, wildfires, and other climate-related factors. Health outcomes included preterm birth, low birthweight, small for gestational age, gestational diabetes, pre-eclampsia/eclampsia, miscarriage/stillbirth and maternal mortality.

Study Appraisal and Synthesis Methods

The scoping review protocol was registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY202410004, January 3, 2024) and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Data were extracted by 2 authors; quality and risk of bias was assessed independently.

Results

Total of 966 references were screened; 16.35% (k=158) met inclusion criteria. The majority of studies (146/158; 92.4%) documented statistically significant and clinically meaningful associations between climate drivers and adverse perinatal health outcomes, including risk of preterm birth, low birthweight, and stillbirth as well as preeclampsia, gestational diabetes, miscarriage, and maternal death. Among the most durable findings: extreme heat exposure in early and late pregnancy were associated with increased risk of preterm birth and stillbirth. Driven in part by large (often population-based) studies and objective outcomes from surveillance data or medical record reviews, studies in this scoping review were evaluated as high quality (scoring 7-9 on the Newcastle-Ottawa Scale). Risk of bias was generally low.

Conclusions

Climate drivers are consistently associated with adverse health outcomes for pregnant people. Continuing education for clinicians, and clinician-patient communications should be expanded to address risks of climate change and extreme weather exposure, especially risks of extreme heat in late-pregnancy. Results from this review should inform multilevel interventions to address adverse health effects of climate during pregnancy as well as practice advisories, protocols, checklists, and clinical guidelines in obstetrics.