Hybrid Cell Membrane-Engineered Nanocarrier for Triple-Action Strategy to Address Pseudomonas aeruginosa Infection (Adv. Sci. 6/2025)

IF 14.1 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2025-02-10 DOI:10.1002/advs.202570036
Shunhao Zhang, Tianyu Chen, Weitong Lu, Yunfeng Lin, Mi Zhou, Xiaoxiao Cai
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Abstract

Hybrid Cell Membrane-Engineered Nanocarrier

In article number 2411261 by Mi Zhou, Xiaoxiao Cai, and co-workers, a hybrid cell membraneengineered nanocarrier called TTob@NPM is developed to address recalcitrant Pseudomonas aeruginosa lung infection with three mechanisms: inflammation targeting, bacteria killing, and immunomodulation, representing a potent antibiotic delivery system with both simplicity and efficacy. This is analogous to the traditional Chinese story of “Monkey Hit White-Skeleton Demon Thrice”. White-Skeleton Demon changes herself into three different forms while Monkey sees through all her disguises and finally subdues her.

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混合膜工程纳米载体对铜绿假单胞菌感染的三作用策略(Adv. science . 6/2025)
在2411261号文章中,Zhou Mi, Xiaoxiao Cai及其同事开发了一种名为TTob@NPM的混合细胞膜工程纳米载体,通过三种机制:炎症靶向,细菌杀伤和免疫调节来治疗顽固性铜绿假单胞菌肺部感染,代表了一种简单有效的有效的抗生素递送系统。这类似于中国传统的“猴打白骨精三”的故事。白骨妖变成了三种不同的形态,猴子识破了她的伪装,最终制服了她。
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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