A Novel “Three-in-One” Copper-Based Metal-Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy (Adv. Sci. 6/2025)

IF 14.1 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Advanced Science Pub Date : 2025-02-10 DOI:10.1002/advs.202570032
Shuohui Dong, Haolin Cao, Ye Yuan, Shuo Liang, Zhendong Fu, Wei Shi, Qian Xu, Xiang Zhao, Jingnan Shi, Xiaoxiao Guo, Kaili Guo, Sanyuan Hu, Guangyong Zhang, Lizeng Gao, Lei Chen
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Abstract

“Three-in-One” Nanozyme for Tumor Therapy

This cover illustration depicts three angels supporting a net that captures tumor cells. In article number 2413422 by Lei Chen, Shuohui Dong, and co-workers, a “Three-in-One” Cu-based metalorganic framework nanozyme is developed, aiming to eradicate colorectal cancer and overcome chemoresistance through apoptosis, cuproptosis, and facilitating the degradation of hypoxia-inducible factor-1a.

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新型“三合一”铜基金属-有机框架纳米酶根除结直肠癌并克服肿瘤化疗耐药(Adv. Sci. 6/2025)
“三合一”肿瘤治疗纳米酶这幅封面插图描绘了三个天使支撑着一张捕获肿瘤细胞的网。在2413422号文章中,陈磊、董硕辉等人开发了一种“三合一”的铜基金属有机框架纳米酶,旨在通过细胞凋亡、铜降解和促进缺氧诱导因子-1a的降解来根除结直肠癌和克服化疗耐药。
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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