N-Carbamimidoyl-2,2,2-Trifluoro-N′-Arylacetimidamides as Important Intermediates for the Synthesis of 3-Amino-4-Aryl-5-(Trifluoromethyl)-1H-1,2,4-Triazoles
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引用次数: 0
Abstract
A novel series of N-carbamimidoyl-2,2,2-trifluoro-N′-arylacetimidamides (3a–j) have been prepared via condensation of 2,2,2-trifuoroacetimidoyl chlorides with guanidine in the presence Na and in dry EtOH solvent at ambient temperature. Then, these key intermediates were applied for the synthesized of 3-amino-4-aryl-5-(trifluoromethyl)-1H-1,2,4-triazoles (4a–j) under oxidative cyclization reaction in the presence of KI/I2 as an oxidant system and DMSO solvent. The target compounds were produced in high yields and without the need for isolation.
期刊介绍：
The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.
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