{"title":"Black Phosphorus Nanosheet-Based Composite Biomaterials for the Enhanced Repair of Infectious Bone Defects.","authors":"Wen Yin, Shouye Sun, Hongyuan Yao, Wenbo Li, Yutao Cui, Chuangang Peng","doi":"10.1021/acsbiomaterials.4c02263","DOIUrl":null,"url":null,"abstract":"<p><p>Infectious bone defects pose significant challenges in orthopedic practice, marked by persistent bacterial infection and ongoing inflammatory responses. Recent advancements in bone tissue engineering have led to the development of biomaterials with both antibacterial properties and the ability to promote bone regeneration, offering new solutions to these complex issues. Black phosphorus nanosheets (BPNS), a unique two-dimensional material, demonstrate exceptional biocompatibility, bioactivity, and antibacterial properties. Their combination of osteogenic, antibacterial, and anti-inflammatory effects positions BPNS as an ideal candidate for addressing bone defects complicated by infection. This Review explores the potential of BPNS-based composite biomaterials in repairing infectious bone defects, discussing their molecular mechanisms for antibacterial activity, including intrinsic antibacterial properties, photothermal therapy (PTT), photodynamic therapy (PDT), and drug delivery. The application of BPNS in treating infectious bone defects, through hydrogels, scaffolds, coatings, and fibers, is also discussed. The Review emphasizes the transformative role of BPNS in bone tissue engineering and advocates for continued research and development in this promising field.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":"1317-1337"},"PeriodicalIF":5.5000,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.4c02263","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Infectious bone defects pose significant challenges in orthopedic practice, marked by persistent bacterial infection and ongoing inflammatory responses. Recent advancements in bone tissue engineering have led to the development of biomaterials with both antibacterial properties and the ability to promote bone regeneration, offering new solutions to these complex issues. Black phosphorus nanosheets (BPNS), a unique two-dimensional material, demonstrate exceptional biocompatibility, bioactivity, and antibacterial properties. Their combination of osteogenic, antibacterial, and anti-inflammatory effects positions BPNS as an ideal candidate for addressing bone defects complicated by infection. This Review explores the potential of BPNS-based composite biomaterials in repairing infectious bone defects, discussing their molecular mechanisms for antibacterial activity, including intrinsic antibacterial properties, photothermal therapy (PTT), photodynamic therapy (PDT), and drug delivery. The application of BPNS in treating infectious bone defects, through hydrogels, scaffolds, coatings, and fibers, is also discussed. The Review emphasizes the transformative role of BPNS in bone tissue engineering and advocates for continued research and development in this promising field.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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