Cheng-Hang Liu , Mengyang Xu , Jianke Du , Yang Ni , Qiyun Luo , Ziyan Wang , Wenyue Tan , Yunfang He , Linrun Zhang , Xiaodong Jia , Xingzeng Zhao
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引用次数: 0
Abstract
We present a practical synthesis of 2′-hydroxy-3′,4′,5′,6′-tetramethoxyacetophenone, a multi-substituted benzene derivative, via CuCl-catalyzed Ullmann-type coupling reaction with MeONa. 2′-Hydroxy-3′,4′,5′,6′-tetramethoxyacetophenone is the key intermediate for the total synthesis of various polymethoxyflavones. Subsequently, nobiletin, tangeretin, and gardenin A–D, are synthesized from this intermediate.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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