Prognostic value of the preoperative ratio of fibrinogen to prealbumin in patients undergoing radical resection for lung cancer

Abstract

Background

To investigate the significance of preoperative fibrinogen-to-prealbumin ratio (FPR) in the prognosis of non-small cell lung cancer.

Methods

The clinical follow-up pathological data of 289 patients who underwent radical lung cancer resection and were pathologically diagnosed with non-small cell lung cancer after surgery were retrospectively analysed, and the FPR value was calculated according to the serological test results within 1 week before surgery. The cut-off value of FPR was obtained by analysing the receiver operating characteristic curve (ROC). Kaplan–Meier analysis was used to describe the survival curve, and Cox proportional hazards model was used to explore the risk factors affecting prognosis.

Results

When the FPR value was 10.96, the Youden index was the highest, with a sensitivity of 62.4% and a specificity of 69.6%. The cumulative five-year survival rate in the low FPR group was significantly higher than that in the high FPR group (81.4% versus 54.7%). Univariate and multivariate analyses showed that FPR level was a risk factor for prognosis.

Conclusion

There is a correlation between FPR level and the prognosis of lung cancer patients, and early intervention should be implemented for patients with high FPR before surgery.