The use of human tissue surrogates in anatomical modeling for gunshot wounds simulations: an overview about "how to do" experimental terminal ballistics.

IF 4.8 3区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2025-01-24 eCollection Date: 2025-01-01 DOI:10.3389/fbioe.2025.1536423
Lucas Meciano Pereira Dos Santos, Marcelo Rodrigues da Cunha, Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Ana Paula Bernardes da Rosa, Leandro Moreira Tempest, José Augusto Parola da Cruz, Rogério Leone Buchaim, João Paulo Mardegan Issa
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Abstract

Human tissue simulating materials are currently used in scientific research mainly because they help to avoid possible ethical issues, unlike what happens with studies involving live animals and/or human cadavers. The use of ballistic gelatin as a human soft tissue surrogate stands out, although other types of materials can be used, including polyurethane and polydimethylsiloxane in the simulation of bones and skin respectively, not to mention some computational models that completely replace the physical use of surrogate models for gunshot wound simulation. The use of human tissue surrogates can be useful in reconstructing the dynamics of a crime scene when important forensic traces cannot be found. In the absence of projectiles but in possession of the possible firearm used in the crime, for example, it is possible to verify whether the weapon in question actually fired the fatal gunshot by comparing the injury found on the victim with the injury produced on the simulant material that best represents the anatomical area impacted, as indicated in the literature. Thus, scientific advances in experimental research in terminal ballistics with tissue surrogates can positively impact applied forensic sciences in the search for better technical assistance to the justice system in solving criminal situations.

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人体组织替代物在枪伤模拟解剖模型中的应用:关于“如何做”实验末端弹道的概述。
人体组织模拟材料目前用于科学研究,主要是因为它们有助于避免可能的伦理问题,不像涉及活体动物和/或人类尸体的研究所发生的问题。尽管可以使用其他类型的材料,包括聚氨酯和聚二甲基硅氧烷分别在骨骼和皮肤的模拟中使用,但使用弹道明胶作为人体软组织替代品脱颖而出,更不用说一些完全取代物理使用替代模型进行枪伤模拟的计算模型。当无法找到重要的法医痕迹时,使用人体组织替代物可用于重建犯罪现场的动态。例如,在没有抛射物但拥有犯罪中可能使用的枪支的情况下,可以通过比较受害者身上发现的伤害与最能代表受影响解剖区域的模拟材料上造成的伤害来核实所涉武器是否确实发射了致命的一枪,如文献所示。因此,利用组织替代物进行终端弹道实验研究的科学进展可以积极影响法医科学的应用,为司法系统解决刑事案件提供更好的技术援助。
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来源期刊
Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering
CiteScore
8.30
自引率
5.30%
发文量
2270
审稿时长
12 weeks
期刊介绍: The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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