Microneedle-based nanodrugs for tumor immunotherapy

IF 11.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY Journal of Controlled Release Pub Date : 2025-04-10 Epub Date: 2025-02-13 DOI:10.1016/j.jconrel.2025.02.003

Tianye Wang , Hongyu Liu , Meng Li , Zao Ji , Xinyuan Zhang , Nan Wang , Ying Chen , Jin Sun , Funan Liu

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Abstract

Microneedles have emerged as a promising and effective method for delivering therapeutic drugs and immunobiologics to treat various diseases. It is widely recognized that immune therapy has limited efficacy in solid tumors due to physical barriers and the immunosuppressive tumor microenvironment. Microneedle-based nanodrugs (NDMNs) offer a novel approach to overcome these limitations. These tiny needles are designed to load a variety of inorganic and organic nanoparticles, antigen vaccines, gene drugs, oncolytic viruses, and more. Utilizing microneedle arrays, NDMNs can effectively penetrate the skin barrier, delivering drugs precisely to the tumor site or immunoactive regions within the skin. Additionally, by designing and optimizing the microneedle structure, shape, and functionality, NDMNs enable precise drug release and efficient penetration, thereby enhancing the efficacy of tumor immunotherapy. In this review, we comprehensively discuss the pivotal role of NDMNs in cancer immunotherapy, summarizing innovative microneedle design strategies, mechanisms of immune activation, and delivery strategies of various nanodrugs. Furthermore, we explore the current clinical realities, limitations, and future prospects of NDMNs in tumor immunotherapy.

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基于微针的纳米药物增强肿瘤免疫治疗。

微针已成为一种有前途的有效方法，用于输送治疗药物和免疫生物制剂来治疗各种疾病。由于物理屏障和肿瘤微环境的免疫抑制作用，免疫治疗对实体瘤的疗效有限。基于微针的纳米药物（NDMNs）提供了一种克服这些限制的新方法。这些微小的针头被设计用来装载各种无机和有机纳米颗粒、抗原疫苗、基因药物、溶瘤病毒等。利用微针阵列，ndmn可以有效地穿透皮肤屏障，将药物精确地输送到皮肤内的肿瘤部位或免疫活性区域。此外，通过设计和优化微针的结构、形状和功能，NDMNs可以实现精确的药物释放和有效的渗透，从而提高肿瘤免疫治疗的疗效。在本文中，我们全面讨论了NDMNs在癌症免疫治疗中的关键作用，总结了创新的微针设计策略、免疫激活机制以及各种纳米药物的递送策略。此外，我们还探讨了NDMNs在肿瘤免疫治疗中的临床现状、局限性和未来前景。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.